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Identification of Aberrantly Expressed lncRNAs Involved in Orthodontic Force Using a Subpathway Strategy
المؤلفون المشاركون
Guo, Xinxing
Wang, Jianning
Chen, Jing
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The aim of the study was to identify key long noncoding RNAs (lncRNA) and related subpathways in the periodontal ligament tissue following orthodontic force.
Methods.
We adopt a novelty subpathway strategy to identify lncRNAs competitively regulated functions and the key competitive lncRNAs in periodontal ligament disorders after undergoing orthodontic force.
To begin with, patients with orthodontics in our hospital were enrolled in our research.
The relationship of lncRNA-mRNA was established through shared predicted miRNA by using the hypergeometric test, Jaccard coefficient standardization, and the Pearson coefficient to determine the valid interaction relationship.
After embedding screened lncRNA interactions to pathways, the significant subpathways were recognized by lenient distance and Wallenius approximation methods to calculate the false discovery rate value of each subpathway.
Results.
The lncRNA-mRNA intersections including 263 lncRNAs, 1,599 mRNAs, and 3,762 interacting pairs were obtained.
The enriched mRNAs were further enriched into various candidate pathways such as the PI3K-Akt signaling pathway.
Several subpathways were screened, including the PI3K-Akt signaling pathway, 04510_1 focal adhesion, and p53 signaling pathway, respectively.
The network of pathway-lncRNA-mRNA was constructed.
Several key lncRNAs including DNAJC3-AS1, WDFY3-AS2, LINC00482, and DLEU2 were screened.
Conclusions.
DNAJC3-AS1, WDFY3-AS2, LINC00482, and DLEU2 as aberrantly expressed lncRNAs involved in orthodontic force might play crucial roles in periodontal ligament disease pathogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Xinxing& Wang, Jianning& Chen, Jing. 2019. Identification of Aberrantly Expressed lncRNAs Involved in Orthodontic Force Using a Subpathway Strategy. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130777
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Xinxing…[et al.]. Identification of Aberrantly Expressed lncRNAs Involved in Orthodontic Force Using a Subpathway Strategy. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1130777
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Xinxing& Wang, Jianning& Chen, Jing. Identification of Aberrantly Expressed lncRNAs Involved in Orthodontic Force Using a Subpathway Strategy. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130777
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130777
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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