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Good Tolerance of Citrate Accumulation due to Plasma Exchange among Patients with Acute-on-Chronic Liver Failure: A Prospective, Observational Study
المؤلفون المشاركون
Ma, Yuanji
Xu, Yan
Chen, Fang
Wang, Ying
Bai, Lang
Tang, Hong
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
To assess the tolerance of citrate accumulation due to plasma exchange (PE) among patients with acute-on-chronic liver failure (ACLF).
Methods.
A prospective, observational study was conducted among patients with ACLF who received heparin anticoagulation during PE-centered therapy without filtration and dialysis.
Citrate accumulation was defined as the value of total calcium (Catot) to ionized calcium (Caion) ratio (Catot/Caion) greater than or equal to 2.5 (Catot/Caion≥2.5).
Results.
Fifty-four patients were enrolled.
The mean age and MELD score were 50.0 ± 11.3 years old and 25 ± 7, respectively.
Thirty-three patients had liver cirrhosis.
The total 3-month survival rate was 57.4% (31/54).
The mean Catot/Caion at the time before PE was 2.05 ± 0.14.
Catot/Caion≥2.5 occurred in 100.0% (54/54) and 29.6% (16/54) of patients with mean Catot/Caion of 4.34 ± 1.52 and 2.36 ± 0.32 immediately after PE and 1 hour after PE, respectively, and these levels were much higher than those before PE (p<0.01).
However, all values returned to lower than 2.5 by the next morning with no difference from those before PE (2.10 ± 0.14 versus 2.05 ± 0.14, p>0.05).
Hypocalcemia (ionized calcium) and mild alkalosis were the main metabolic alterations.
No symptoms associated with hypocalcemia occurred.
Conclusions.
Citrate accumulation is well tolerated by patients with ACLF who receive PE-centered therapy without filtration and dialysis.
This study is regeristed with ChiCTR-OOC-17013618.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Yuanji& Xu, Yan& Chen, Fang& Wang, Ying& Bai, Lang& Tang, Hong. 2018. Good Tolerance of Citrate Accumulation due to Plasma Exchange among Patients with Acute-on-Chronic Liver Failure: A Prospective, Observational Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130935
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Yuanji…[et al.]. Good Tolerance of Citrate Accumulation due to Plasma Exchange among Patients with Acute-on-Chronic Liver Failure: A Prospective, Observational Study. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1130935
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Yuanji& Xu, Yan& Chen, Fang& Wang, Ying& Bai, Lang& Tang, Hong. Good Tolerance of Citrate Accumulation due to Plasma Exchange among Patients with Acute-on-Chronic Liver Failure: A Prospective, Observational Study. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130935
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130935
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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