High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor?
المؤلفون المشاركون
Orlien, Stian Magnus Staurung
Ahmed, Tekabe Abdosh
Ismael, Nejib Yusuf
Berhe, Nega
Lauritzen, Trine
Gundersen, Svein Gunnar
Johannessen, Asgeir
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Recent studies have identified chewing of khat (Catha edulis) as an independent risk factor for liver injury; however, the pathogenetic mechanism remains poorly understood.
Case series have found markers of autoimmune hepatitis in patients with khat-related liver disease, suggesting that khat chewing might trigger an autoimmune response.
The aims of the present study were (i) to assess the prevalence of autoantibodies typical for autoimmune liver diseases in a healthy population in Ethiopia and (ii) to explore the hypothesis that khat usage triggers autoimmunity.
Methods.
Consenting adults (≥18 years) without known autoimmune disease or manifest liver disease were included.
One-hundred-and-sixty-nine individuals with current khat use were compared to 104 individuals who never used khat.
Seroprevalence of antinuclear (ANA), antismooth muscle (SMA), and antimitochondrial antibodies (AMA) were determined and compared between the groups using logistic regression models to adjust for age and sex.
Results.
Overall, 2.6% of the study subjects were positive for ANA, 15.4% for SMA, and 25.6% for AMA.
When comparing khat users to nonusers, ANA was detected in 4.1% vs.
0% (p=0.047), SMA in 16.0% vs.
14.4% (p=0.730), and AMA in 24.9% vs.
26.9% (p=0.704).
ANA was excluded from multivariable analysis since there was no seropositive in the reference group.
After adjusting for sex and age, no significant association between khat use and SMA or AMA was found.
Conclusions.
No association between khat usage and the seropresence of SMA or AMA was found, weakening the hypothesis that khat-related liver injury is mediated through autoimmune mechanisms.
However, the seroprevalences of AMA and SMA were strikingly high in this Ethiopian population compared to global estimates, suggesting that diagnostic algorithms for autoimmune liver diseases developed in Europe and North America might lead to misdiagnosis of patients on the African continent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Orlien, Stian Magnus Staurung& Ahmed, Tekabe Abdosh& Ismael, Nejib Yusuf& Berhe, Nega& Lauritzen, Trine& Gundersen, Svein Gunnar…[et al.]. 2018. High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor?. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130939
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Orlien, Stian Magnus Staurung…[et al.]. High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor?. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1130939
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Orlien, Stian Magnus Staurung& Ahmed, Tekabe Abdosh& Ismael, Nejib Yusuf& Berhe, Nega& Lauritzen, Trine& Gundersen, Svein Gunnar…[et al.]. High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor?. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130939
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130939
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر