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Effect of Efavirenz on Endogenous Progesterone Concentrations and Contraceptive Outcomes among Ugandan HIV Infected Women Coadministering EthinylestradiolLevonorgestrel
المؤلفون المشاركون
Munkwase, Grant
Bisaso, Kuteesa R.
Kakaire, Othman
Nanzigu, Sarah
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This study assessed the effect of efavirenz mid-dose plasma concentrations on mid-luteal endogenous progesterone concentrations and contraceptive outcomes among 49 HIV infected women coadministering ethinylestradiol/levonorgestrel, including 34 HIV positive women on Highly Active Antiretroviral Therapy (HAART) and 15 HAART naïve HIV infected women, purposively selected from Mulago Hospital, Uganda.
A blood sample was collected once between days 20 and 22 of each woman’s menstrual cycle for measuring endogenous progesterone and efavirenz concentrations by electrochemiluminescence technology and High Performance Liquid Chromatography (HPLC), respectively.
Descriptive statistical analysis and correlation and logistic regression analysis were done using SPSS v.21 and R3.1.
Efavirenz showed a weak positive linear relationship with endogenous progesterone at efavirenz concentrations below 12 μg/ml.
Based on serum endogenous progesterone, the observed hormonal contraceptives failure rate (24.5%) was higher than expected (maximum 8%).
A higher proportion of HIV positive women on efavirenz based HAART (26.5%) was at risk of contraceptive failure than their HIV infected HAART naïve counterparts (20%) though it was not statistically significant (p=0.63).
Efavirenz mid-dose plasma concentrations seem to have no significant effect on mid-luteal endogenous progesterone concentrations and contraceptive outcomes among HIV infected Ugandan women coadministering ethinylestradiol/levonorgestrel oral pills.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Munkwase, Grant& Bisaso, Kuteesa R.& Kakaire, Othman& Nanzigu, Sarah. 2017. Effect of Efavirenz on Endogenous Progesterone Concentrations and Contraceptive Outcomes among Ugandan HIV Infected Women Coadministering EthinylestradiolLevonorgestrel. AIDS Research and Treatment،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1130948
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Munkwase, Grant…[et al.]. Effect of Efavirenz on Endogenous Progesterone Concentrations and Contraceptive Outcomes among Ugandan HIV Infected Women Coadministering EthinylestradiolLevonorgestrel. AIDS Research and Treatment No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1130948
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Munkwase, Grant& Bisaso, Kuteesa R.& Kakaire, Othman& Nanzigu, Sarah. Effect of Efavirenz on Endogenous Progesterone Concentrations and Contraceptive Outcomes among Ugandan HIV Infected Women Coadministering EthinylestradiolLevonorgestrel. AIDS Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1130948
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130948
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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