Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals
المؤلفون المشاركون
Drazilova, Sylvia
Janicko, Martin
Kristian, Pavol
Schreter, Ivan
Jarcuska, Peter
Skladany, Lubomir
Oltman, Marian
Szantova, Maria
Krkoska, Dusan
Mazuchova, Eva
Piesecka, Lubica
Vahalova, Veronika
Rac, Marek
Virag, Ladislav
Liptakova, Adriana
Ondrasova, Miriam
Koller, Tomas
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Aims.
Chronic hepatitis C is a systemic disease and type 2 diabetes mellitus (T2DM) belongs to more common extrahepatic.
The aim of this study was to (i) explore the prevalence of impaired fasting glucose (IFG) and T2DM in patients with chronic hepatitis C, (ii) explore the effect of direct acting antivirals (DAA) treatment on the glycemia, and (iii) explore the factors that modulate the effect of DAA treatment on glycemia in patients with chronic hepatitis C.
Methods.
We performed a longitudinal retrospective observational study focused on the patients undergoing DAA treatment of chronic hepatitis C.
Data about glycemia, history of diabetes, hepatitis C virus, treatment, and liver status, including elastography, were obtained at baseline (before treatment start), at the end of treatment and 12 weeks after the end of treatment.
Patients were treated with various regimens of direct acting antivirals.
Results.
We included 370 patients; 45.9% had F4 fibrosis.
At baseline, the prevalence of T2DM increased with the degree of fibrosis (F0-F2 14.4%, F3 21.3%, and F4 31.8%, p=0.004).
Fasting glycemia also increased with the degree of fibrosis (F0-F2 5.75±0.18 F3 5.84±0.17, and F4 6.69±0.2 mmol/L, p=0.001).
We saw significant decrease of glycemia after treatment in all patients, but patients without T2DM or IFG from 6.21±0.12 to 6.08±0.15 mmol/L (p=0.002).
The decrease was also visible in treatment experienced patients and patients with Child-Pugh A cirrhosis.
Conclusion.
We confirmed that the prevalence of either T2DM or IFG increases in chronic hepatitis C patients with the degree of fibrosis.
The predictive factors for T2DM were, besides F4, fibrosis also higher age and BMI.
Significant decrease of fasting glycemia after the DAA treatment was observed in the whole cohort and in subgroups of patients with T2DM, IFG, cirrhotic, and treatment experienced patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Drazilova, Sylvia& Janicko, Martin& Skladany, Lubomir& Kristian, Pavol& Oltman, Marian& Szantova, Maria…[et al.]. 2018. Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Drazilova, Sylvia…[et al.]. Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1130987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Drazilova, Sylvia& Janicko, Martin& Skladany, Lubomir& Kristian, Pavol& Oltman, Marian& Szantova, Maria…[et al.]. Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر