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Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism
المؤلفون المشاركون
Bernier, Raphael
Luhrs, Kyleen
Ward, Tracey
Hudac, Caitlin M.
Stessman, Holly A. F.
Eichler, Evan E.
Gerdts, Jennifer
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The purpose of this study was to examine the confluence of genetic and familial risk factors in children with Autism Spectrum Disorder (ASD) with distinct de novo genetic events.
We hypothesized that gene-disrupting mutations would be associated with reduced rates of familial psychiatric disorders relative to structural mutations.
Participants included families of children with ASD in four groups: de novo duplication copy number variations (DUP, n=62), de novo deletion copy number variations (DEL, n=74), de novo likely gene-disrupting mutations (LGDM, n=267), and children without a known genetic etiology (NON, n=2111).
Familial rates of psychiatric disorders were calculated from semistructured interviews.
Results indicated overall increased rates of psychiatric disorders in DUP families compared to DEL and LGDM families, specific to paternal psychiatric histories, and particularly evident for depressive disorders.
Higher rates of depressive disorders in maternal psychiatric histories were observed overall compared to paternal histories and higher rates of anxiety disorders were observed in paternal histories for LGDM families compared to DUP families.
These findings support the notion of an additive contribution of genetic etiology and familial factors are associated with ASD risk and highlight critical need for continued work targeting these relationships.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luhrs, Kyleen& Ward, Tracey& Hudac, Caitlin M.& Gerdts, Jennifer& Stessman, Holly A. F.& Eichler, Evan E.…[et al.]. 2017. Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism. Autism Research and Treatment،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1131068
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luhrs, Kyleen…[et al.]. Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism. Autism Research and Treatment No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1131068
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luhrs, Kyleen& Ward, Tracey& Hudac, Caitlin M.& Gerdts, Jennifer& Stessman, Holly A. F.& Eichler, Evan E.…[et al.]. Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism. Autism Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1131068
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131068
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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