Prevalence of Sero-Molecular Markers of Hepatitis C and B Viruses among Patients with β-Thalassemia Major in Northern West Bank, Palestine
المؤلفون المشاركون
Samarah, Fekri
Dumaidi, Kamal
Al-Jawabreh, Amer
Rabayaa, Maha
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
HCV and HBV present a great challenge in the management of β-thalassemia patients.
Objective.
The present study aimed to determine the prevalence of both HBV and HCV in multitransfused-dependent β-thalassemia patients in northern West Bank, Palestine, using sero-molecular markers.
Methods.
Serum sample from 139 multitransfused β-thalassemia patients were tested for HBV and HCV markers including HBsAg, anti-HBc, anti-HBs, HBV-DNA, and anti-HCV and HCV-RNA.
Demographic data and selected clinical parameters were collected by means of a questionnaire and from the patients’ medical files.
Results and Conclusion.
The mean (±SD) age of patients was 18.1 years (±10.6).
The overall prevalence of the HCV was 10% (14/139), which is 50 times higher than the normal Palestinian population (0.2%).
Of which, 3 were positive for anti-HCV alone, 7 positives for HCV-RNA alone, and 4 positives for both anti-HCV and PCR-RNA.
On the other hand, low prevalence of HBV was detected at a level of 0.7% (1/139).
Only one patient had HCV-HBV coinfection.
Twenty-five patients (19%) were positive for anti-HBc, while 99 (71%) were immune with the anti-HBs level above 10 IU/mL.
Anti-HBc was insignificantly high (P=0.07) in HCV-positive cases.
In conclusion, the prevalence of HCV among β-thalassemia patients is considered high compared to normal population.
Determination of HCV prevalence should be based on the detection of both HCV-RNA and anti-HCV.
On the contrary, HBV showed a low prevalence.
A follow-up schedule and administration of booster dose of HBV vaccine is strongly recommended for β-thalassemia patients whose anti-HBs level <10 IU/ml.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dumaidi, Kamal& Al-Jawabreh, Amer& Samarah, Fekri& Rabayaa, Maha. 2018. Prevalence of Sero-Molecular Markers of Hepatitis C and B Viruses among Patients with β-Thalassemia Major in Northern West Bank, Palestine. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1131113
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dumaidi, Kamal…[et al.]. Prevalence of Sero-Molecular Markers of Hepatitis C and B Viruses among Patients with β-Thalassemia Major in Northern West Bank, Palestine. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1131113
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dumaidi, Kamal& Al-Jawabreh, Amer& Samarah, Fekri& Rabayaa, Maha. Prevalence of Sero-Molecular Markers of Hepatitis C and B Viruses among Patients with β-Thalassemia Major in Northern West Bank, Palestine. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1131113
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131113
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر