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Development of New Tools to Detect Colistin-Resistance among Enterobacteriaceae Strains
المؤلفون المشاركون
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-25، 25ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-05
دولة النشر
مصر
عدد الصفحات
25
التخصصات الرئيسية
الملخص EN
The recent discovery of the plasmid-mediated mcr-1 gene conferring resistance to colistin is of clinical concern.
The worldwide screening of this resistance mechanism among samples of different origins has highlighted the urgent need to improve the detection of colistin-resistant isolates in clinical microbiology laboratories.
Currently, phenotypic methods used to detect colistin resistance are not necessarily suitable as the main characteristic of the mcr genes is the low level of resistance that they confer, close to the clinical breakpoint recommended jointly by the CLSI and EUCAST expert systems (S ≤ 2 mg/L and R > 2 mg/L).
In this context, susceptibility testing recommendations for polymyxins have evolved and are becoming difficult to implement in routine laboratory work.
The large number of mechanisms and genes involved in colistin resistance limits the access to rapid detection by molecular biology.
It is therefore necessary to implement well-defined protocols using specific tools to detect all colistin-resistant bacteria.
This review aims to summarize the current clinical microbiology diagnosis techniques and their ability to detect all colistin resistance mechanisms and describe new tools specifically developed to assess plasmid-mediated colistin resistance.
Phenotyping, susceptibility testing, and genotyping methods are presented, including an update on recent studies related to the development of specific techniques.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bardet, Lucie& Rolain, J. M.. 2018. Development of New Tools to Detect Colistin-Resistance among Enterobacteriaceae Strains. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-25.
https://search.emarefa.net/detail/BIM-1131150
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bardet, Lucie& Rolain, J. M.. Development of New Tools to Detect Colistin-Resistance among Enterobacteriaceae Strains. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-25.
https://search.emarefa.net/detail/BIM-1131150
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bardet, Lucie& Rolain, J. M.. Development of New Tools to Detect Colistin-Resistance among Enterobacteriaceae Strains. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-25.
https://search.emarefa.net/detail/BIM-1131150
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131150
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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