Bifidobacterium lactis Ameliorates the Risk of Food Allergy in Chinese Children by Affecting Relative Percentage of Treg and Th17 Cells
المؤلفون المشاركون
Liu, Qingbin
Jing, Wei
Wang, Wei
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We aimed to explore the therapeutic effect of Bifidobacterium lactis on food allergy by investigating the percentage of Treg and Th17 cells in Chinese children and related molecular mechanisms.
A total of 256 children with food allergy were evenly assigned into two groups: BG, the children received 10 ml B.
lactis (1 × 106/ml) daily, and CG, the children received the solution without B.
lactis daily for three months.
Allergic symptoms, serum IgE, and food antigen-specific IgE were measured.
A mouse allergy model was established by using shrimp tropomyosin and treated with B.
lactis.
Relative mRNA levels of Treg- and Th17-associated cytokines were measured by using quantitative PCR.
The percentage of Treg and Th17 cells in spleen were measured by using flow cytometry.
After 3-month therapy, the allergic symptoms of the BG were remarkably reduced when compared with the CG (P<0.05).
Serum levels of IgE and food antigen-specific IgE were decreased too (P<0.05).
Similar results were also found in a mouse allergy model.
After B.
lactis treatment, the relative mRNA level of FoxP3 was significantly enhanced in the B.
lactis therapy group when compared to positive controls.
In addition, relative mRNA levels of FoxP3 and TGF-β associated with Treg cells were increased, whereas relative mRNA levels of IL-17A and IL-23 associated with Th17 were reduced.
B.
lactis treatment significantly increased the ratio of Treg and Th17 cells in a mouse allergy model (P<0.05).
B.
lactis effectively alleviates allergic symptoms by increasing the ratio of Treg and Th17 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Qingbin& Jing, Wei& Wang, Wei. 2018. Bifidobacterium lactis Ameliorates the Risk of Food Allergy in Chinese Children by Affecting Relative Percentage of Treg and Th17 Cells. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131180
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Qingbin…[et al.]. Bifidobacterium lactis Ameliorates the Risk of Food Allergy in Chinese Children by Affecting Relative Percentage of Treg and Th17 Cells. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1131180
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Qingbin& Jing, Wei& Wang, Wei. Bifidobacterium lactis Ameliorates the Risk of Food Allergy in Chinese Children by Affecting Relative Percentage of Treg and Th17 Cells. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131180
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131180
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر