Elevated Serum Total Bilirubin Level Is Associated with Poor Outcomes in Pediatric Patients with Sepsis-Associated Liver Injury
المؤلفون المشاركون
Cui, Yun
Shan, Yijun
Chen, Rongxin
Wang, Chunxia
Zhang, Yucai
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
The aim of this study was to assess the prognostic value of the serum total bilirubin (TBIL) level in pediatric patients with sepsis-associated liver injury (SALI).
Methods.
We performed a retrospective study of patients with SALI admitted to the pediatric intensive care unit (PICU) in Shanghai Children’s Hospital between December 2012 and December 2015.
Serum TBIL concentration was determined within 72 h after PICU admission.
Results.
Seventy-two patients with SALI were included in this study.
The overall mortality rate was 36.1% (26/72).
The serum levels of TBIL of patients were significantly higher in the nonsurvivor group than the survivor group.
Cox regression analysis indicated that the elevated serum TBIL level within 72 hours after admission was an independent risk factor of mortality in patients with SALI.
Furthermore, the area under the receiver-operating characteristic (ROC) curve (AUC) for TBIL was 0.736 (95% confidence interval (CI): 0.614–0.858, P=0.001), in which the optimal cut-off value was 64.5 μmol/L.
The combined index named “TBIL” and “TBA” showed an AUC of 0.745 (0.626–0.865) for predicting the prognosis in patients with SALI.
In addition, the Kaplan–Meier curve indicated that the 28-day survival rate was significantly lower in patients with higher serum TBIL levels (≥64.5 μmol/L) or higher value of TBIL and TBA (≥−0.8902).
Conclusions.
Elevated serum TBIL level is associated with poor outcomes in pediatric SALI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cui, Yun& Shan, Yijun& Chen, Rongxin& Wang, Chunxia& Zhang, Yucai. 2018. Elevated Serum Total Bilirubin Level Is Associated with Poor Outcomes in Pediatric Patients with Sepsis-Associated Liver Injury. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131182
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cui, Yun…[et al.]. Elevated Serum Total Bilirubin Level Is Associated with Poor Outcomes in Pediatric Patients with Sepsis-Associated Liver Injury. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131182
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cui, Yun& Shan, Yijun& Chen, Rongxin& Wang, Chunxia& Zhang, Yucai. Elevated Serum Total Bilirubin Level Is Associated with Poor Outcomes in Pediatric Patients with Sepsis-Associated Liver Injury. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131182
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131182
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر