Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage

المؤلفون المشاركون

Wu, Xingchen
Reinikainen, Petri
Kapanen, Mika
Vierikko, Tuula
Ryymin, Pertti
Kellokumpu-Lehtinen, Pirkko-Liisa

المصدر

Contrast Media & Molecular Imaging

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-09-19

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Background and Purpose.

Although several methods have been developed to predict the outcome of patients with prostate cancer, early diagnosis of individual patient remains challenging.

The aim of the present study was to correlate tumor perfusion parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinical prognostic factors and further to explore the diagnostic value of DCE-MRI parameters in early stage prostate cancer.

Patients and Methods.

Sixty-two newly diagnosed patients with histologically proven prostate adenocarcinoma were enrolled in our prospective study.

Transrectal ultrasound-guided biopsy (12 cores, 6 on each lobe) was performed in each patient.

Pathology was reviewed and graded according to the Gleason system.

DCE-MRI was performed and analyzed using a two-compartmental model; quantitative parameters including volume transfer constant (Ktrans), reflux constant (Kep), and initial area under curve (iAUC) were calculated from the tumors and correlated with prostate-specific antigen (PSA), Gleason score, and clinical stage.

Results.

Ktrans (0.11 ± 0.02 min−1 versus 0.16 ± 0.06 min−1; p<0.05), Kep (0.38 ± 0.08 min−1 versus 0.60 ± 0.23 min−1; p<0.01), and iAUC (14.33 ± 2.66 mmoL/L/min versus 17.40 ± 5.97 mmoL/L/min; p<0.05) were all lower in the clinical stage T1c tumors (tumor number, n=11) than that of tumors in clinical stage T2 (n=58).

Serum PSA correlated with both tumor Ktrans (r=0.304, p<0.05) and iAUC (r=0.258, p<0.05).

Conclusions.

Our study has confirmed that DCE-MRI is a promising biomarker that reflects the microcirculation of prostate cancer.

DCE-MRI in combination with clinical prognostic factors may provide an effective new tool for the basis of early diagnosis and treatment decisions.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Xingchen& Reinikainen, Petri& Kapanen, Mika& Vierikko, Tuula& Ryymin, Pertti& Kellokumpu-Lehtinen, Pirkko-Liisa. 2018. Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131355

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Xingchen…[et al.]. Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131355

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Xingchen& Reinikainen, Petri& Kapanen, Mika& Vierikko, Tuula& Ryymin, Pertti& Kellokumpu-Lehtinen, Pirkko-Liisa. Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131355

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1131355