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Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage
المؤلفون المشاركون
Wu, Xingchen
Reinikainen, Petri
Kapanen, Mika
Vierikko, Tuula
Ryymin, Pertti
Kellokumpu-Lehtinen, Pirkko-Liisa
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Purpose.
Although several methods have been developed to predict the outcome of patients with prostate cancer, early diagnosis of individual patient remains challenging.
The aim of the present study was to correlate tumor perfusion parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinical prognostic factors and further to explore the diagnostic value of DCE-MRI parameters in early stage prostate cancer.
Patients and Methods.
Sixty-two newly diagnosed patients with histologically proven prostate adenocarcinoma were enrolled in our prospective study.
Transrectal ultrasound-guided biopsy (12 cores, 6 on each lobe) was performed in each patient.
Pathology was reviewed and graded according to the Gleason system.
DCE-MRI was performed and analyzed using a two-compartmental model; quantitative parameters including volume transfer constant (Ktrans), reflux constant (Kep), and initial area under curve (iAUC) were calculated from the tumors and correlated with prostate-specific antigen (PSA), Gleason score, and clinical stage.
Results.
Ktrans (0.11 ± 0.02 min−1 versus 0.16 ± 0.06 min−1; p<0.05), Kep (0.38 ± 0.08 min−1 versus 0.60 ± 0.23 min−1; p<0.01), and iAUC (14.33 ± 2.66 mmoL/L/min versus 17.40 ± 5.97 mmoL/L/min; p<0.05) were all lower in the clinical stage T1c tumors (tumor number, n=11) than that of tumors in clinical stage T2 (n=58).
Serum PSA correlated with both tumor Ktrans (r=0.304, p<0.05) and iAUC (r=0.258, p<0.05).
Conclusions.
Our study has confirmed that DCE-MRI is a promising biomarker that reflects the microcirculation of prostate cancer.
DCE-MRI in combination with clinical prognostic factors may provide an effective new tool for the basis of early diagnosis and treatment decisions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Xingchen& Reinikainen, Petri& Kapanen, Mika& Vierikko, Tuula& Ryymin, Pertti& Kellokumpu-Lehtinen, Pirkko-Liisa. 2018. Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131355
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Xingchen…[et al.]. Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131355
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Xingchen& Reinikainen, Petri& Kapanen, Mika& Vierikko, Tuula& Ryymin, Pertti& Kellokumpu-Lehtinen, Pirkko-Liisa. Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131355
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131355
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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