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Multimodal PETMRI Imaging Results Enable Monitoring the Side Effects of Radiation Therapy
المؤلفون المشاركون
Szigeti, Krisztián
Hegedűs, Nikolett
Kovács, Noémi
Máthé, Domokos
Horváth, Ildikó
Veres, Dániel S
Bachmann, Michael
Bergmann, Ralf
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Radiotherapy is one of the most frequently applied treatments in oncology.
Tissue-absorbed ionizing radiation damages not only targeted cells but the surrounding cells too.
The consequent long-term induced oxidative stress, irreversible tissue damage, or second malignancies draw attention to the urgent need of a follow-up medical method by which personalized treatment could be attained and the actually dose-limiting organ could be monitored in the clinical practice.
We worked out a special hemisphere irradiation technique for mice which mimics the radiation exposure during radiotherapy.
We followed up the changes of possible brain imaging biomarkers of side effects, such as cerebral blood flow, vascular endothelial function, and cellular metabolic processes for 60 days.
BALB/c mice were divided into two groups (n=6 per group) based on the irradiation doses (5 and 20 Gy).
After the irradiation procedure arterial spin labeling (ASL), diffusion-weighted imaging (DWI) in magnetic resonance modality and [18F]fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) scans of the brain were obtained at several time points (3, 7, 30, and 60 days after the irradiation).
Significant physiological changes were registered in the brain of animals following the irradiation by both applied doses.
Elevated standard uptake values were detected all over the brain by FDG-PET studies 2 months after the irradiation.
The apparent diffusion coefficients from DWI scans significantly decreased one month after the irradiation procedure, while ASL studies did not show any significant perfusion changes in the brain.
Altogether, our sensitive multimodal imaging protocol seems to be an appropriate method for follow-up of the health status after radiation therapy.
The presented approach makes possible parallel screening of healthy tissues and the effectiveness of tumor therapy without any additional radiation exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kovács, Noémi& Szigeti, Krisztián& Hegedűs, Nikolett& Horváth, Ildikó& Veres, Dániel S& Bachmann, Michael…[et al.]. 2018. Multimodal PETMRI Imaging Results Enable Monitoring the Side Effects of Radiation Therapy. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131467
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kovács, Noémi…[et al.]. Multimodal PETMRI Imaging Results Enable Monitoring the Side Effects of Radiation Therapy. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1131467
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kovács, Noémi& Szigeti, Krisztián& Hegedűs, Nikolett& Horváth, Ildikó& Veres, Dániel S& Bachmann, Michael…[et al.]. Multimodal PETMRI Imaging Results Enable Monitoring the Side Effects of Radiation Therapy. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131467
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131467
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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