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Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis
المؤلفون المشاركون
Huang, Bingsheng
Feng, Shi-Ting
Jia, Yingmei
Luo, Yanji
Xu, Ling
Li, Zi-Ping
Wang, Yi
Huang, Kun
Chen, Jie
Zhang, Yu
Chen, Minhu
Ni, Dong
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
We propose a computer-aided method to assess response to drug treatment, using CT imaging-based volumetric and density measures in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and diffuse liver metastases.
Methods.
Twenty-five patients with GEP-NETs with diffuse liver metastases were enrolled.
Pre- and posttreatment CT examinations were retrospectively analyzed.
Total tumor volume (volume) and mean volumetric tumor density (density) were calculated based on tumor segmentation on CT images.
The maximum axial diameter (tumor size) for each target tumor was measured on pre- and posttreatment CT images according to Response Evaluation Criteria In Solid Tumors (RECIST).
Progression-free survival (PFS) for each patient was measured and recorded.
Results.
Correlation analysis showed inverse correlation between change of volume and density (Δ(V + D)), change of volume (ΔV), and change of tumor size (ΔS) with PFS (r = −0.653, P=0.001; r = −0.617, P=0.003; r = −0.548, P=0.01, respectively).
There was no linear correlation between ΔD and PFS (r = −0.226, P=0.325).
Conclusion.
The changes of volume and density derived from CT images of all lesions showed a good correlation with PFS and may help assess treatment response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yi& Huang, Kun& Chen, Jie& Luo, Yanji& Zhang, Yu& Jia, Yingmei…[et al.]. 2018. Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yi…[et al.]. Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yi& Huang, Kun& Chen, Jie& Luo, Yanji& Zhang, Yu& Jia, Yingmei…[et al.]. Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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