Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation
المؤلفون المشاركون
He, Dakuo
Wang, Zhengsong
Pan, Zhen
Shi, Jiahui
Sun, Shouxin
Hou, Yue
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-30
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The pharmaceutical tablet manufacturing process (PTMP) via wet granulation holds a critical position in pharmaceutical industry.
The interest in integrating mechanistic process modeling into the pharmaceutical development has been increased because simulation model is a prerequisite for process design, analysis, control, and optimization.
So the simulation modeling for PTMP via wet granulation is very necessary and significant.
This study aims at proposing a simulation modeling framework for PTMP via spray fluidized bed granulation (SFBG), which is one of the most widely used wet granulation techniques in pharmaceutical industry.
For SFBG, a simulation model that simultaneously involves the influences of operating variables and material attributes on average particle size (APS) is firstly developed, and then a drying model to determine the particle moisture content is introduced to be coupled with the established model predicting APS.
For PTMP, considering the important effect of porosity on tablet qualities, a model describing the changes in tablet porosity is developed based on a promoted form of the Heckel equation, and then several recognized models that are all related to porosity are introduced or constructed to calculate important tablet quality indexes.
The feasibility and effectiveness of the developed simulation models are validated by performing a computational experimental study to explore the scientific understanding of process and process quality control.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhengsong& Pan, Zhen& He, Dakuo& Shi, Jiahui& Sun, Shouxin& Hou, Yue. 2019. Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation. Complexity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1131499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhengsong…[et al.]. Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation. Complexity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1131499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhengsong& Pan, Zhen& He, Dakuo& Shi, Jiahui& Sun, Shouxin& Hou, Yue. Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation. Complexity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1131499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر