Construction and Evaluation of the Tumor-Targeting, Cell-Penetrating Multifunctional Molecular Probe iCREKA
المؤلفون المشاركون
Wu, Hu-bing
Wang, Lijuan
Wang, Quan-shi
Han, Yan-jian
Zhou, Wen-lan
Huang, Shun
Li, Hongsheng
Wang, Meng
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
A novel tumor stroma targeting and membrane-penetrating cyclic peptide, named iCREKA, was designed and labeled by fluorescein isothiocyanate (FITC) and positron emitter 18F to build the tumor-targeting tracers.
The FITC-iCREKA was proved to have significantly higher cellular uptake in the glioma U87 cells in the presence of activated MMP-2 than that in absence of activated MMP-2 by cells fluorescence test in vitro.
The tumor tissue fluorescence microscope imaging demonstrated that FITC-iCREKA accumulated in the walls of the blood vessels and the surrounding stroma in the glioma tumor at 1 h after intravenous injection.
While at 3 h after injection, FITC-iCREKA was found to be uptaken in the tumor cells.
However, the control FITC-CREKA can only be found in the tumor stroma, not in the tumor cells, no matter at 1 h or 3 h after injection.
The whole-animal fluorescence imaging showed that the glioma tumor could be visualized clearly with high fluorescence signal.
The microPET/CT imaging further demonstrated that 18F-iCREKA could target U87MG tumor in vivo from 30 min to 2 h after injection.
The present study indicated the iCREKA had the capacity of tumor stroma targeting and the membrane-penetrating.
It was potential to be developed as the fluorescent and PET tracers for tumor imaging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Lijuan& Li, Hongsheng& Wang, Quan-shi& Wu, Hu-bing& Han, Yan-jian& Zhou, Wen-lan…[et al.]. 2018. Construction and Evaluation of the Tumor-Targeting, Cell-Penetrating Multifunctional Molecular Probe iCREKA. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131546
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Lijuan…[et al.]. Construction and Evaluation of the Tumor-Targeting, Cell-Penetrating Multifunctional Molecular Probe iCREKA. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131546
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Lijuan& Li, Hongsheng& Wang, Quan-shi& Wu, Hu-bing& Han, Yan-jian& Zhou, Wen-lan…[et al.]. Construction and Evaluation of the Tumor-Targeting, Cell-Penetrating Multifunctional Molecular Probe iCREKA. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131546
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131546
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر