L1CAM High Expression Associates with Poor Prognosis in Glioma but Does Not Correlate with C11orf95-RELA Fusion
المؤلفون المشاركون
Zeng, Jing
Xi, Shao-Yan
Wang, Fang
Liao, Hua-Dong
Yang, Yuan-Zhong
Hu, Wan-Ming
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The latest WHO guideline of CNS tumor defined a RELA fusion-positive ependymoma type with extremely poor prognosis, and the expression of L1CAM was correlated well with the presence of RELA fusion.
However, the L1CAM protein expression in large sample gliomas other than ependymoma, its relationship with the RELA gene and its prognostic significance remained unknown.
We examined the expression of L1CAM in 565 glioma cases (WHO grade I-IV).
The L1CAM IHC-positive cases were selected to test RELA fusion with FISH break-apart probes.
L1CAM was positive in 109 cases (19.29%) of all 565 glioma cases, with 18.27% in low-grade gliomas and 19.84% in high-grade gliomas, respectively.
Unlike ependymoma, L1CAM protein expression was not correlated with the C11orf95-RELA fusion gene in other gliomas, but it had correction with the patient age (older than 45-year-old, p=0.006), ATRX mutation (p=0.003) and Ki67 (p=0.007).
High expression of L1CAM was an independent prognostic factor in our cohort.
Further analysis demonstrated that L1CAM strong positive expression was significantly associated with poor prognosis in gliomas, both in our cohort (p<0.001) and TCGA (p<0.009) dataset.
Although uncorrelated with C11orf95-RELA fusion, L1CAM was a significant poor prognostic marker in glioma patients.
More aggressive treatment should be taken for these patients and L1CAM might be a promising therapeutic target in glioma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeng, Jing& Xi, Shao-Yan& Wang, Fang& Liao, Hua-Dong& Yang, Yuan-Zhong& Hu, Wan-Ming. 2020. L1CAM High Expression Associates with Poor Prognosis in Glioma but Does Not Correlate with C11orf95-RELA Fusion. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131578
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeng, Jing…[et al.]. L1CAM High Expression Associates with Poor Prognosis in Glioma but Does Not Correlate with C11orf95-RELA Fusion. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1131578
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeng, Jing& Xi, Shao-Yan& Wang, Fang& Liao, Hua-Dong& Yang, Yuan-Zhong& Hu, Wan-Ming. L1CAM High Expression Associates with Poor Prognosis in Glioma but Does Not Correlate with C11orf95-RELA Fusion. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131578
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131578
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر