Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model
المؤلفون المشاركون
Oudot, Alexandra
Vrigneaud, Jean-Marc
Denat, Franck
Bellaye, Pierre-Simon
Raguin, Olivier
Bichat, Francis
Vaslin, Anne
Maby-El Hajjami, Hélène
Zanna, Claudio
Vuagniaux, Grégoire
Fumoleau, Pierre
Brunotte, François
Collin, Bertrand
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Debio 1143, a potent orally available SMAC mimetic, targets inhibitors of apoptosis proteins (IAPs) members and is currently in clinical trials.
In this study, nuclear imaging evaluated the effects of Debio 1143 on tumor cell death and metabolism in a triple-negative breast cancer (TNBC) cell line (MDA-MB-231)-based animal model.
Methods.
Apoptosis induced by Debio 1143 was assessed by FACS (caspase-3, annexin 5 (A5)), binding of 99mTc-HYNIC-Annexin V, and a cell proliferation assay.
99mTc-HYNIC-Annexin V SPECT and [18F]-FDG PET were also performed in mice xenografted with MDA-MB-231 cells.
Results.
Debio 1143 induced early apoptosis both in vitro and in vivo 6 h after treatment.
Debio 1143 inhibited tumor growth, which was associated with a decreased tumor [18F]-FDG uptake when measured during treatment.
Conclusions.
This imaging study combining SPECT and PET showed the early proapoptotic effects of Debio 1143 resulting in a robust antitumor activity in a preclinical TNBC model.
These imaging biomarkers represent valuable noninvasive tools for translational and clinical research in TNBC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bellaye, Pierre-Simon& Oudot, Alexandra& Vrigneaud, Jean-Marc& Raguin, Olivier& Bichat, Francis& Vaslin, Anne…[et al.]. 2018. Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131590
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bellaye, Pierre-Simon…[et al.]. Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131590
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bellaye, Pierre-Simon& Oudot, Alexandra& Vrigneaud, Jean-Marc& Raguin, Olivier& Bichat, Francis& Vaslin, Anne…[et al.]. Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131590
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131590
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر