Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients
المؤلفون المشاركون
Mauriello, A.
Catapano, Carlo V.
Bonanno, Elena
Scimeca, Manuel
Urbano, Nicoletta
Bonfiglio, Rita
Mapelli, Sarah Natalia
Carbone, Giuseppina Maria
Ciuffa, Sara
Tavolozza, Mario
Schillaci, Orazio
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The main aim of this study was to investigate the putative association among the presence of prostate cancer cells, defined as prostate osteoblast-like cells (POLCs), and showing the expression of typical morphological and molecular characteristics of osteoblasts, the development of bone metastasis within 5 years of diagnosis, and the uptake of 18F-choline evaluated by PET/CT analysis.
To this end, prostate biopsies (n = 110) were collected comprising 44 benign lesions and 66 malignant lesions.
Malignant lesions were further subdivided into two groups: biopsies from patients that had clinical evidence of bone metastasis (BM+, n = 23) and biopsies from patients that did not have clinical evidence of bone metastasis within 5 years (BM−, n = 43).
Paraffin serial sections were obtained from each specimen to perform histological classifications and immunohistochemical (IHC) analysis.
Small fragments of tissue were used to perform ultrastructural and microanalytical investigations.
IHC demonstrated the expression of markers of epithelial-to-mesenchymal transition (VIM), bone mineralization, and osteoblastic differentiation (BMP-2, PTX-3, RUNX2, RANKL, and VDR) in prostate lesions characterized by the presence of calcium-phosphate microcalcifications and high metastatic potential.
Ultrastructural studies revealed the presence of prostate cancer cells with osteoblast phenotype close to microcalcifications.
Noteworthy, PET/CT analysis showed higher uptake of 18F-choline in BM+ lesions with high positivity (≥300/500 cells) for RUNX2 and/or RANKL immunostaining.
Although these data require further investigations about the molecular mechanisms of POLCs generation and role in bone metastasis, our study can open new and interesting prospective in the management of prostate cancer patients.
The presence of POLCs along with prostate microcalcifications may become negative prognostic markers of the occurrence of bone metastases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Scimeca, Manuel& Urbano, Nicoletta& Bonfiglio, Rita& Mapelli, Sarah Natalia& Catapano, Carlo V.& Carbone, Giuseppina Maria…[et al.]. 2018. Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131684
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Scimeca, Manuel…[et al.]. Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1131684
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Scimeca, Manuel& Urbano, Nicoletta& Bonfiglio, Rita& Mapelli, Sarah Natalia& Catapano, Carlo V.& Carbone, Giuseppina Maria…[et al.]. Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131684
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131684
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر