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Characterization of the Oxidative Stress in Renal IschemiaReperfusion-Induced Cardiorenal Syndrome Type 3
المؤلفون المشاركون
Caio-Silva, Wellington
da Silva Dias, Danielle
Junho, Carolina Victoria Cruz
Panico, Karine
Neres-Santos, Raquel Silva
Pelegrino, Milena Trevisan
Pieretti, Joana Claudio
Seabra, Amedea Barozzi
De Angelis, Kátia
Carneiro-Ramos, Marcela Sorelli
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
In kidney disease (KD), several factors released into the bloodstream can induce a series of changes in the heart, leading to a wide variety of clinical situations called cardiorenal syndrome (CRS).
Reactive oxygen species (ROS) play an important role in the signaling and progression of systemic inflammatory conditions, as observed in KD.
The aim of the present study was to characterize the redox balance in renal ischemia/reperfusion-induced cardiac remodeling.
C57BL/6 male mice were subjected to occlusion of the left renal pedicle, unilateral, for 60 min, followed by reperfusion for 8 and 15 days, respectively.
The following redox balance components were evaluated: catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (FRAP), NADPH oxidase (NOX), nitric oxide synthase (NOS), hydrogen peroxide (H2O2), and the tissue bioavailability of nitric oxide (NO) such as S-nitrosothiol (RSNO) and nitrite (NO2−).
The results indicated a process of renoprotection in both kidneys, indicated by the reduction of cellular damage and some oxidant agents.
We also observed an increase in the activity of antioxidant enzymes, such as SOD, and an increase in NO bioavailability.
In the heart, we noticed an increase in the activity of NOX and NOS, together with increased cell damage on day 8, followed by a reduction in protein damage on day 15.
The present study concludes that the kidneys and heart undergo distinct processes of damage and repair at the analyzed times, since the heart is a secondary target of ischemic kidney injury.
These results are important for a better understanding of the cellular mechanisms involved in CRS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Caio-Silva, Wellington& da Silva Dias, Danielle& Junho, Carolina Victoria Cruz& Panico, Karine& Neres-Santos, Raquel Silva& Pelegrino, Milena Trevisan…[et al.]. 2020. Characterization of the Oxidative Stress in Renal IschemiaReperfusion-Induced Cardiorenal Syndrome Type 3. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131757
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Caio-Silva, Wellington…[et al.]. Characterization of the Oxidative Stress in Renal IschemiaReperfusion-Induced Cardiorenal Syndrome Type 3. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1131757
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Caio-Silva, Wellington& da Silva Dias, Danielle& Junho, Carolina Victoria Cruz& Panico, Karine& Neres-Santos, Raquel Silva& Pelegrino, Milena Trevisan…[et al.]. Characterization of the Oxidative Stress in Renal IschemiaReperfusion-Induced Cardiorenal Syndrome Type 3. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131757
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131757
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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