Differential Expression and Prognostic Value of Cytoplasmic and Nuclear Cyclin D1 in Prostate Cancer

المؤلفون المشاركون

Xu, Huan
Guo, Fei
Sun, Yinghao
Cao, Zhi
Chen, Xi
Xu, Yalong
Ji, Jin
He, Jingyi
Wang, Fubo

المصدر

BioMed Research International

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-05-31

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Cyclin D1 (CCND1) has been revealed as a key regulating protein in cell cycle (G1 phase) and plays a critical role in promoting tumor development.

The purpose of our study was to investigate the associations between CCND1 and biochemical recurrence of prostate cancer (PCa).

We performed immunostaining of CCND1 on a tissue microarray and evaluated the CCND1 expression levels based on the intensity and extent of staining.

The clinical data was collected, and the follow-up data was received by searching our follow-up database called “PC-follow”.

We revealed that CCND1 expression patterns were different between cytoplasm and nucleus in this study, and the expression of CCND1 in adjacent normal tissues was higher than that in PCa tissues (P<0.001), while nuclear CCND1 showed the opposite distribution characteristic (P<0.001).

The cytoplasmic CCND1 also showed correlation with several clinical factors, e.g., tumor T stage (P<0.001), Gleason score (P=0.028), positive surgical margin (P=0.037), and capsule invasion (P=0.04).

We also revealed that cytoplasmic CCND1 is a protective prognostic factor in the biochemical recurrence (BCR) free time analysis (P=0.002).

However, the nuclear CCND1 showed no correlation with clinical factors or prognostic value in this study.

This study found that cytoplasmic and nuclear CCND1 have significant different expression patterns in PCa tissues, and cytoplasmic CCND1 has a certain prognostic value in the BCR analysis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Cao, Zhi& Chen, Xi& Xu, Yalong& Guo, Fei& Ji, Jin& Xu, Huan…[et al.]. 2020. Differential Expression and Prognostic Value of Cytoplasmic and Nuclear Cyclin D1 in Prostate Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131840

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Cao, Zhi…[et al.]. Differential Expression and Prognostic Value of Cytoplasmic and Nuclear Cyclin D1 in Prostate Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1131840

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Cao, Zhi& Chen, Xi& Xu, Yalong& Guo, Fei& Ji, Jin& Xu, Huan…[et al.]. Differential Expression and Prognostic Value of Cytoplasmic and Nuclear Cyclin D1 in Prostate Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131840

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1131840