Anti-Inflammatory, Barrier-Protective, and Antiwrinkle Properties of Agastache rugosa Kuntze in Human Epidermal Keratinocytes
المؤلفون المشاركون
Lee, Yoonjin
Lim, Hye-Won
Ryu, In Wang
Huang, Yu-Hua
Park, Minsik
Chi, Young Min
Lim, Chang-Jin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This work aimed to assess the skin-beneficial properties of Agastache rugosa Kuntze, an herbal medication used to treat different types of disorders in traditional folk medicine.
The total phenolic compounds and total antiradical, nitrite scavenging, superoxide scavenging, antielastase, and antihyaluronidase activities of a hot water extract of A.
rugosa Kuntze leaves (ARE) were spectrophotometrically determined.
Intracellular reactive oxygen species (ROS) was fluorometrically quantitated using 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA).
Inducible nitric oxide synthase (iNOS) and filaggrin were evaluated using Western analysis.
Real-time quantitative RT-PCR was used to measure filaggrin mRNA.
Caspase-14 activity was determined using a fluorogenic substrate.
ARE contained the total phenolic content of 38.9 mg gallic acid equivalent/g extract and exhibited 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical, superoxide radical, and nitrite scavenging activities with the SC50 values of 2.9, 1.4, and 1.7 mg/mL, respectively.
ARE exerted suppressive activities on nitric oxide (NO) and ROS levels elevated by lipopolysaccharide (LPS) or tumor necrosis factor-α (TNF-α) in HaCaT keratinocytes.
It attenuated the LPS-stimulated expression of iNOS.
ARE augmented the UV-B-reduced filaggrin expression on both protein and mRNA levels and was capable of upregulating the UV-B-reduced caspase-14 activity.
ARE inhibited in vitro elastase and hyaluronidase activities associated with the wrinkling process.
ARE, at the concentrations used, did not interfere with the viability of HaCaT keratinocytes.
These findings preliminarily imply that the leaves of A.
rugosa possess desirable cosmetic potentials, such as anti-inflammatory, barrier protective, and antiwrinkle activities, which infers their skin healing potentials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Yoonjin& Lim, Hye-Won& Ryu, In Wang& Huang, Yu-Hua& Park, Minsik& Chi, Young Min…[et al.]. 2020. Anti-Inflammatory, Barrier-Protective, and Antiwrinkle Properties of Agastache rugosa Kuntze in Human Epidermal Keratinocytes. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Yoonjin…[et al.]. Anti-Inflammatory, Barrier-Protective, and Antiwrinkle Properties of Agastache rugosa Kuntze in Human Epidermal Keratinocytes. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1131919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Yoonjin& Lim, Hye-Won& Ryu, In Wang& Huang, Yu-Hua& Park, Minsik& Chi, Young Min…[et al.]. Anti-Inflammatory, Barrier-Protective, and Antiwrinkle Properties of Agastache rugosa Kuntze in Human Epidermal Keratinocytes. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر