Airflow and Particle Deposition in Acinar Models with Interalveolar Septal Walls and Different Alveolar Numbers
المؤلفون المشاركون
Xi, Jinxiang
Talaat, Mohamed
Tanbour, Hesham
Talaat, Khaled
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-25
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Unique features exist in acinar units such as multiple alveoli, interalveolar septal walls, and pores of Kohn.
However, the effects of such features on airflow and particle deposition remain not well quantified due to their structural complexity.
This study aims to numerically investigate particle dynamics in acinar models with interalveolar septal walls and pores of Kohn.
A simplified 4-alveoli model with well-defined geometries and a physiologically realistic 45-alveoli model was developed.
A well-validated Lagrangian tracking model was used to simulate particle trajectories in the acinar models with rhythmically expanding and contracting wall motions.
Both spatial and temporal dosimetries in the acinar models were analyzed.
Results show that collateral ventilation exists among alveoli due to pressure imbalance.
The size of interalveolar septal aperture significantly alters the spatial deposition pattern, while it has an insignificant effect on the total deposition rate.
Surprisingly, the deposition rate in the 45-alveoli model is lower than that in the 4-alveoli model, indicating a stronger particle dispersion in more complex models.
The gravity orientation angle has a decreasing effect on acinar deposition rates with an increasing number of alveoli retained in the model; such an effect is nearly negligible in the 45-alveoli model.
Breath-holding increased particle deposition in the acinar region, which was most significant in the alveoli proximal to the duct.
Increasing inhalation depth only slightly increases the fraction of deposited particles over particles entering the alveolar model but has a large influence on dispensing particles to the peripheral alveoli.
Results of this study indicate that an empirical correlation for acinar deposition can be developed based on alveolar models with reduced complexity; however, what level of geometry complexity would be sufficient is yet to be determined.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xi, Jinxiang& Talaat, Mohamed& Tanbour, Hesham& Talaat, Khaled. 2018. Airflow and Particle Deposition in Acinar Models with Interalveolar Septal Walls and Different Alveolar Numbers. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1131944
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xi, Jinxiang…[et al.]. Airflow and Particle Deposition in Acinar Models with Interalveolar Septal Walls and Different Alveolar Numbers. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1131944
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xi, Jinxiang& Talaat, Mohamed& Tanbour, Hesham& Talaat, Khaled. Airflow and Particle Deposition in Acinar Models with Interalveolar Septal Walls and Different Alveolar Numbers. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1131944
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131944
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر