Development of Autophagy Signature-Based Prognostic Nomogram for Refined Glioma Survival Prognostication
المؤلفون المشاركون
Fan, Yuxiang
Peng, Xinyu
Li, Baoqin
Zhao, Gang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-07
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
The current glioma classification could be optimized to cover such a separate and individualized prognosis ranging from a few months to over ten years.
Considering its highly conserved role and potential in therapies, autophagy might be a promising element to be incorporated as a refinement for improved survival prognostication.
The expression and RNA-seq data of 881 glioma patients from the Gene Expression Omnibus and The Cancer Genome Atlas were included, mapped with autophagy-related genes.
Weighted gene coexpression network analysis and Cox regression analysis were used for the autophagy signature establishment, which composed of MUL1, NPC1, and TRIM13.
Validations were represented by Kaplan-Meier plots and receiver operating curves (ROC).
Cluster analysis suggested the IDH1 mutant involved in the favorable prognosis of the signature clusters.
The signature was also immune-related shown by the Gene Ontology analysis and the Gene Set Enrichment Analysis.
The high signature risk group held a higher ESTIMATE score (p=2.6e−11) and stromal score (p=1.8e−10).
CD276 significantly correlated with the signature (r=0.51, p<0.05).
The final nomogram integrated with the autophagy signature, IDH1 mutation, and pathological grade was built with accuracy and discrimination (1-year survival AUC=0.812, 5-year survival AUC=0.822, and 10-year survival AUC=0.834).
Its prognostic value and clinical utility were well-defined by the superiority in the comparisons with the current World Health Organization glioma classification in ROC (p<0.05) and decision curve analysis.
The autophagy signature-based IDH1 mutation and grade nomogram refined glioma classification for a more individualized and clinically applicable survival estimation and inspired potential autophagy-related therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Yuxiang& Peng, Xinyu& Li, Baoqin& Zhao, Gang. 2020. Development of Autophagy Signature-Based Prognostic Nomogram for Refined Glioma Survival Prognostication. BioMed Research International،Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1132044
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Yuxiang…[et al.]. Development of Autophagy Signature-Based Prognostic Nomogram for Refined Glioma Survival Prognostication. BioMed Research International No. 2020 (2020), pp.1-23.
https://search.emarefa.net/detail/BIM-1132044
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Yuxiang& Peng, Xinyu& Li, Baoqin& Zhao, Gang. Development of Autophagy Signature-Based Prognostic Nomogram for Refined Glioma Survival Prognostication. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1132044
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132044
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر