CUMS Promotes the Development of Premature Ovarian Insufficiency Mediated by Nerve Growth Factor and Its Receptor in Rats
المؤلفون المشاركون
Zheng, Qun
Zhang, Ning
Wang, Wenqian
Ding, Mingxing
Chen, Haohao
Fu, Xiaoyan
Pan, Xiaoming
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This study aimed to investigate whether chronic unpredictable mild stress (CUMS) affects follicular development in ovaries through the nerve growth factor (NGF)/high affinity nerve growth factor receptor, the Tropomyosin-related kinase A (TrkA) receptor, mediated signaling pathway and to reveal the relationship between chronic stress and premature ovarian insufficiency (POI) development.
In this experiment, a CUMS rat model was constructed.
It was found that serum estradiol (E2), anti-Mullerian hormone (AMH), and gonadotropin-releasing hormone (GnRH) levels decreased, while follicle-stimulating hormone (FSH) levels increased.
The expression of NGF, TrkA, p75, and FSHR in ovarian tissue decreased significantly.
The expression levels of TrkA and p75 protein in ovarian stroma and small follicles were observed by an immunofluorescence assay.
In addition, the numbers of small follicles were significantly reduced.
The expression of TrkA, p75, and FSHR in CUMS ovarian tissue was upregulated by exogenous NGF in vitro.
Furthermore, after treatment with NGF combined with FSH, E2 secretion in ovarian tissue culture supernatant of CUMS rats also increased significantly.
Therefore, CUMS downregulates NGF and TrkA and promotes the occurrence of POI in rats.
Exogenous NGF and FSH can upregulate the NGF receptor, E2, and AMH in vitro, and improve the rat ovarian function.
Future studies may associate these results with female population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Xiaoyan& Zheng, Qun& Zhang, Ning& Ding, Mingxing& Pan, Xiaoming& Wang, Wenqian…[et al.]. 2020. CUMS Promotes the Development of Premature Ovarian Insufficiency Mediated by Nerve Growth Factor and Its Receptor in Rats. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132182
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Xiaoyan…[et al.]. CUMS Promotes the Development of Premature Ovarian Insufficiency Mediated by Nerve Growth Factor and Its Receptor in Rats. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1132182
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Xiaoyan& Zheng, Qun& Zhang, Ning& Ding, Mingxing& Pan, Xiaoming& Wang, Wenqian…[et al.]. CUMS Promotes the Development of Premature Ovarian Insufficiency Mediated by Nerve Growth Factor and Its Receptor in Rats. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132182
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132182
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر