Maximin Efficiencies under Treatment-Dependent Costs and Outcome Variances for Parallel, AABB, and ABBA Designs
المؤلف
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-01
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
If there are no carryover effects, AB/BA crossover designs are more efficient than parallel (A/B) and extended parallel (AA/BB) group designs.
This study extends these results in that (a) optimal instead of equal treatment allocation is examined, (b) allowance for treatment-dependent outcome variances is made, and (c) next to treatment effects, also treatment by period interaction effects are examined.
Starting from a linear mixed model analysis, the optimal allocation requires knowledge on intraclass correlations in A and B, which typically is rather vague.
To solve this, maximin versions of the designs are derived, which guarantee a power level across plausible ranges of the intraclass correlations at the lowest research costs.
For the treatment effect, an extensive numerical evaluation shows that if the treatment costs of A and B are equal, or if the sum of the costs of one treatment and measurement per person is less than the remaining subject-specific costs (e.g., recruitment costs), the maximin crossover design is most efficient for ranges of intraclass correlations starting at 0.15 or higher.
For other cost scenarios, the maximin parallel or extended parallel design can also become most efficient.
For the treatment by period interaction, the maximin AA/BB design can be proven to be the most efficient.
A simulation study supports these asymptotic results for small samples.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Candel, Math J. J. M.. 2018. Maximin Efficiencies under Treatment-Dependent Costs and Outcome Variances for Parallel, AABB, and ABBA Designs. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1132195
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Candel, Math J. J. M.. Maximin Efficiencies under Treatment-Dependent Costs and Outcome Variances for Parallel, AABB, and ABBA Designs. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1132195
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Candel, Math J. J. M.. Maximin Efficiencies under Treatment-Dependent Costs and Outcome Variances for Parallel, AABB, and ABBA Designs. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1132195
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132195
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر