Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases
المؤلفون المشاركون
Siriwardena, B. S. M. S.
Karunathilaka, H. D. N. U.
Kumarasiri, P. V. R.
Tilakaratne, W. M.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Nodal metastasis is a critical factor in predicting the prognosis of oral squamous cell carcinoma (OSCC).
When patients present with a clinically positive neck, the treatment of choice is radical neck dissection.
However, management of a clinically negative neck is still a subject of significant controversy.
Aim.
This study was carried out in order to propose a model to predict regional lymph node metastasis of OSCC using histological parameters such as tumour stage, tumour size, pattern of invasion (POI), differentiation of tumour, and host immune response, together with the expression levels of six biomarkers (periostin, HIF-1α, MMP-9, β-catenin, VEGF-C, and EGFR), and, furthermore, to compare the impact of all these parameters on recurrence and 3 yr and 5 yr survival rates.
Materials and Method.
Histological materials collected from the archives were used to evaluate histological parameters and immunohistochemical profiles.
Standard methods were used for immunohistochemistry and for evaluation of results.
Data related to recurrence and survival (3 and 5 years) was also recorded.
Clinical data was collected from patients’ records.
Results.
Male to female ratio was 3 : 1.
The commonest site of OSCC was the buccal mucosa, and majority of them were T3 or T4 tumours presented at stage 4.
62.5% of the tumours were well differentiated.
Three-year and 5-year survival rates were significantly associated with lymph node metastasis and recurrence.
POI was significantly correlated with tumour size, stage, 3-year survival, EGFR, HIF-1α, periostin, and MMP-9 (p<0.05).
Expression of EGFR showed a direct association with metastasis (p<0.05).
Conclusion.
POI, level of differentiation, and expression of EGFR are independent prognostic markers for lymph node metastasis.
Therefore, these parameters may help in treatment planning of a clinically negative neck.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siriwardena, B. S. M. S.& Karunathilaka, H. D. N. U.& Kumarasiri, P. V. R.& Tilakaratne, W. M.. 2020. Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132272
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siriwardena, B. S. M. S.…[et al.]. Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1132272
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siriwardena, B. S. M. S.& Karunathilaka, H. D. N. U.& Kumarasiri, P. V. R.& Tilakaratne, W. M.. Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132272
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132272
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر