![](/images/graphics-bg.png)
Association of Tumor Necrosis Factor Receptor 1 Promoter Gene Polymorphisms (-580 AG and -609 GT) and TNFR1 Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to H. pylori Infection in a Moroccan Population
المؤلفون المشاركون
Badre, Wafaa
Bounder, Ghizlane
Jouimyi, Mohamed R.
Boura, Hasna
Benomar, Hakima
Kettani, Anass
Lebrazi, Halima
Maachi, Fatima
Jouhadi, Hassan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Chronic inflammation due to H.
pylori infection is the risk factor of gastric cancer (GC).
Through its receptor (TNFR1), TNF-α plays a fundamental role in inflammatory, infectious, and tumor processes.
Dysregulation of TNFR1 gene expression could impact many biological processes that can lead to cancer.
This study is aimed at evaluating the association of TNFR1 promoter gene polymorphisms (-580 A/G and -609 G/T) and TNFR1 serum levels with GC and precancerous lesion susceptibility.
Patients suffering from gastric lesions (65 chronic gastritis, 50 precancerous lesions, and 40 GC) related to H.
pylori infection and 63 healthy controls (HC) were involved in this study.
Individuals are genotyped by TNFR1 gene promoter sequencing, and TNFR1 serum levels were measured by the ELISA quantitative method.
Concerning TNFR1 -609 G/T locus, we noticed that the T allele was associated with an attenuated susceptibility to GC (OR=0.4; p value = 0.02).
At the genotypic level and under the recessive model, the TNFR1 -609 TT genotype showed a decreased risk of GC (OR=0.3, p value = 0.03) compared to the combined (GG/GT) genotypes.
TNFR1 serum levels have been increased together with gastric lesion severity (p value < 0.05).
The TNFR1 -609 TT genotype seemed linked to a low level of sTNFR1 compared to GT and GG genotypes (p value = 0.07).
Concerning TNFR1 -580 A/G locus, no significant relation was noticed between this polymorphism and GC susceptibility, as well as with the TNFR1 serum level.
Our results suggest that the TNFR1 -609 T allele appears to have a protective effect against GC.
High levels of TNFR1 serum levels seemed to be associated with the aggressiveness of gastric lesions.
Therefore, our results suggest that TNFR1 -609 T/G polymorphism and the TNFR1 serum levels may be related to GC susceptibility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bounder, Ghizlane& Jouimyi, Mohamed R.& Boura, Hasna& Jouhadi, Hassan& Badre, Wafaa& Benomar, Hakima…[et al.]. 2020. Association of Tumor Necrosis Factor Receptor 1 Promoter Gene Polymorphisms (-580 AG and -609 GT) and TNFR1 Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to H. pylori Infection in a Moroccan Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bounder, Ghizlane…[et al.]. Association of Tumor Necrosis Factor Receptor 1 Promoter Gene Polymorphisms (-580 AG and -609 GT) and TNFR1 Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to H. pylori Infection in a Moroccan Population. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1132508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bounder, Ghizlane& Jouimyi, Mohamed R.& Boura, Hasna& Jouhadi, Hassan& Badre, Wafaa& Benomar, Hakima…[et al.]. Association of Tumor Necrosis Factor Receptor 1 Promoter Gene Polymorphisms (-580 AG and -609 GT) and TNFR1 Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to H. pylori Infection in a Moroccan Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)