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Effect of Baicalin on Bacterial Secondary Infection and Inflammation Caused by H9N2 AIV Infection in Chickens
المؤلفون المشاركون
Zhang, Xinheng
Zhao, Qiqi
Ci, Xiaotong
Chen, Liyi
Lian, Jiamin
Xie, Zi
Lv, Huiyuan
Li, Hongxin
Lin, Wencheng
Zhang, Huanmin
Xie, Qingmei
Chen, Sheng
Ye, Yaqiong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-19
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
H9N2 subtype avian influenza virus (H9N2 AIV) is a low pathogenic virus that is widely prevalent all over the world.
H9N2 AIV causes immunosuppression in the host and often leads to high rates of mortality due to secondary infection with Escherichia.
Due to the drug resistance of bacteria, many antibiotics are not effective in the treatment of secondary bacterial infection.
Therefore, the purpose of this study is to find effective nonantibiotic drugs for the treatment of H9N2 AIV infection-induced secondary bacterial infection and inflammation.
This study proves, for the first time, that baicalin, a Chinese herbal medicine, can regulate Lactobacillus to replace Escherichia induced by H9N2 AIV, so as to resolve the intestinal flora disorder.
In addition, baicalin can effectively prevent intestinal bacterial translocation of SPF chickens’ post-H9N2 AIV infection, thus inhibiting secondary bacterial infection.
Furthermore, baicalin can effectively treat H9N2 AIV-induced inflammation by inhibiting intestinal structural damage, inhibiting damage to ileal mucus layer construction and tight junctions, improving antioxidant capacity, affecting blood biochemical indexes, and inhibiting the production of inflammatory cytokines.
Taken together, these results provide a new theoretical basis for clinical prevention and control of H9N2 AIV infection-induced secondary bacterial infection and inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xinheng& Zhao, Qiqi& Ci, Xiaotong& Chen, Sheng& Chen, Liyi& Lian, Jiamin…[et al.]. 2020. Effect of Baicalin on Bacterial Secondary Infection and Inflammation Caused by H9N2 AIV Infection in Chickens. BioMed Research International،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1132564
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xinheng…[et al.]. Effect of Baicalin on Bacterial Secondary Infection and Inflammation Caused by H9N2 AIV Infection in Chickens. BioMed Research International No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1132564
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xinheng& Zhao, Qiqi& Ci, Xiaotong& Chen, Sheng& Chen, Liyi& Lian, Jiamin…[et al.]. Effect of Baicalin on Bacterial Secondary Infection and Inflammation Caused by H9N2 AIV Infection in Chickens. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1132564
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132564
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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