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Characterization and Functional Analysis of Polyadenylation Sites in Fast and Slow Muscles
المؤلفون المشاركون
Zou, Cheng
Fang, Chengchi
Li, Changchun
Deng, Lulu
Li, Long
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-16
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Many increasing documents have proved that alternative polyadenylation (APA) events with different polyadenylation sites (PAS) contribute to posttranscriptional regulation.
However, little is known about the detailed molecular features of PASs and its role in porcine fast and slow skeletal muscles through microRNAs (miRNAs) and RNA binding proteins (RBPs).
In this study, we combined single-molecule real-time sequencing and Illumina RNA-seq datasets to comprehensively analyze polyadenylation in pigs.
We identified a total of 10,334 PASs, of which 8734 were characterized by reference genome annotation.
32.86% of PAS-associated genes were determined to have more than one PAS.
Further analysis demonstrated that tissue-specific PASs between fast and slow muscles were enriched in skeletal muscle development pathways.
In addition, we obtained 1407 target genes regulated by APA events through potential binding 69 miRNAs and 28 RBPs in variable 3′ UTR regions and some are involved in myofiber transformation.
Furthermore, the de novo motif search confirmed that the most common usage of canonical motif AAUAAA and three types of PASs may be related to the strength of motifs.
In summary, our results provide a useful annotation of PASs for pig transcriptome and suggest that APA may serve as a role in fast and slow muscle development under the regulation of miRNAs and RBPs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Lulu& Li, Long& Zou, Cheng& Fang, Chengchi& Li, Changchun. 2020. Characterization and Functional Analysis of Polyadenylation Sites in Fast and Slow Muscles. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132645
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Lulu…[et al.]. Characterization and Functional Analysis of Polyadenylation Sites in Fast and Slow Muscles. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1132645
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Lulu& Li, Long& Zou, Cheng& Fang, Chengchi& Li, Changchun. Characterization and Functional Analysis of Polyadenylation Sites in Fast and Slow Muscles. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132645
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132645
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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