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What Open-Lung Biopsy Teaches Us about ARDS in COVID-19 Patients: Mechanisms, Pathology, and Therapeutic Implications
المؤلفون المشاركون
Abourida, Yassamine
Rebahi, Houssam
Chichou, Hajar
Fenane, Hicham
Msougar, Yassine
Fakhri, Anas
Hazmiri, Fatima Ezzahra
Ismail, Ayman
Rais, Hanane
Soraa, Nabila
Samkaoui, Mohammed Abdenasser
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Difficulties have risen while managing Acute Respiratory Distress Syndrome (ARDS) caused by COVID-19, although it meets the Berlin definition.
Severe hypoxemia with near-normal compliance was noted along with coagulopathy.
Understanding the precise pathophysiology of this atypical ARDS will assist researchers and physicians in improving their therapeutic approach.
Previous work is limited to postmortem studies, while our report addresses patients under protective lung mechanical ventilation.
An open-lung minithoracotomy was performed in 3 patients who developed ARDS related to COVID-19 and were admitted to the intensive care unit to carry out a pathological and microbiological analysis on lung tissue biopsy.
Diffused alveolar damage with hyaline membranes was found, as well as plurifocal fibrin microthrombi and vascular congestion in all patients’ specimens.
Microbiological cultures were negative, whereas qualitative Reversed Transcriptase Polymerase Chain Reaction (RT-PCR) detected SARS-CoV-2 in the pulmonary parenchyma and pleural fluid in two patients.
COVID-19 causes progressive ARDS with onset of severe hypoxemia, underlying a dual mechanism: shunt effect through diffused alveolar damage and dead space effect through thrombotic injuries in microvascular beds.
It seems reasonable to manage this ventilation-perfusion ratio mismatch using a high dose of anticoagulant combined with glucocorticoids.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abourida, Yassamine& Rebahi, Houssam& Chichou, Hajar& Fenane, Hicham& Msougar, Yassine& Fakhri, Anas…[et al.]. 2020. What Open-Lung Biopsy Teaches Us about ARDS in COVID-19 Patients: Mechanisms, Pathology, and Therapeutic Implications. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abourida, Yassamine…[et al.]. What Open-Lung Biopsy Teaches Us about ARDS in COVID-19 Patients: Mechanisms, Pathology, and Therapeutic Implications. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1132802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abourida, Yassamine& Rebahi, Houssam& Chichou, Hajar& Fenane, Hicham& Msougar, Yassine& Fakhri, Anas…[et al.]. What Open-Lung Biopsy Teaches Us about ARDS in COVID-19 Patients: Mechanisms, Pathology, and Therapeutic Implications. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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