The Role of Endogenous Proteins on the Emulsification of Silicone Oils Used in Vitreoretinal Surgery
المؤلفون المشاركون
Nepita, Irene
Romano, Mario R.
Ravera, Francesca
Santini, Eva
Liggieri, Libero
Pralits, Jan O.
Repetto, Rodolfo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The present work is aimed at investigating the chemicophysical properties of the interface between silicone oils (SOs) used in vitreoretinal surgery and aqueous solutions, in the presence of surfactant biomolecules.
Such molecules are thought to play an important role in the formation of SO emulsions in vitrectomised eyes, in which the natural vitreous body has been replaced with a SO.
In particular, we have measured the interfacial tension (IT) and the interfacial dilational viscoelasticity (DV) of the interface between SO (Siluron 1000) and serum proteins (albumin and γ-globulins) at various concentrations in a Dulbecco alkaline buffer.
The equilibrium IT value is relevant for the onset of emulsification, and the DV influences the stability of an emulsion, once formed.
The study is complemented by preliminary emulsification tests.
The experimental results show that, when proteins are dissolved in the aqueous solution, the rheological properties of the interface change.
The IT decreases significantly for physiological protein concentrations, and the DV modulus achieves high values, even for small protein concentrations.
The emulsification tests confirm that, in the presence of proteins, emulsions are stable on the time scale of months.
We conclude that the measured values of IT in the presence of serum proteins are compatible with the promotion of droplet formation, which, in addition, are expected to be stable against coalescence.
Adsorption of biomolecules at the interface with the SO is, therefore, likely to play an important role in the generation of an emulsion in eyes subjected to vitrectomy.
These findings are relevant to identify strategies to avoid or control the formation of emulsions in eyes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nepita, Irene& Repetto, Rodolfo& Pralits, Jan O.& Romano, Mario R.& Ravera, Francesca& Santini, Eva…[et al.]. 2020. The Role of Endogenous Proteins on the Emulsification of Silicone Oils Used in Vitreoretinal Surgery. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132805
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nepita, Irene…[et al.]. The Role of Endogenous Proteins on the Emulsification of Silicone Oils Used in Vitreoretinal Surgery. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1132805
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nepita, Irene& Repetto, Rodolfo& Pralits, Jan O.& Romano, Mario R.& Ravera, Francesca& Santini, Eva…[et al.]. The Role of Endogenous Proteins on the Emulsification of Silicone Oils Used in Vitreoretinal Surgery. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132805
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132805
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر