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Differentially Expressed mRNAs and Their Long Noncoding RNA Regulatory Network with Helicobacter pylori-Associated Diseases including Atrophic Gastritis and Gastric Cancer
المؤلفون المشاركون
Xing, Chengzhong
Liu, Songyi
Yin, Honghao
Zheng, Shuwen
Chu, Aining
Li, Yizhi
Yuan, Yuan
Gong, Yuehua
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-17
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Background.
Helicobacter pylori (Hp) infection is the strongest risk factor for gastric cancer (GC).
However, the mechanisms of Hp-associated GC remain to be explored.
Methods.
The gene expression profiling (GSE111762) data were downloaded from the GEO database.
Differentially expressed genes (DEGs) between normal samples (NO) and Hp-atrophic gastritis (GA) or Hp-GA and Hp-GC were identified by GEO2R.
Gene Ontology and pathway enrichment analysis were performed using the DAVID database.
lncRNA-TF-mRNA and ceRNA regulation networks were constructed using Cytoscape.
The cross-networks were obtained by overlapping molecules of the above two networks.
GSE27411 and GSE116312 datasets were employed for validation.
Results.
DEGs between NO and Hp-GA are linked to the activity of inward rectifying potassium channels, digestion, etc.
DEGs between Hp-GA and Hp-GC were associated with digestion, positive regulation of cell proliferation, etc.
According to the lncRNA-TF-mRNA network, 63 lncRNAs, 12 TFs, and 209 mRNAs were involved in Hp-GA while 16 lncRNAs, 11 TFs, and 92 mRNAs were contained in the Hp-GC network.
In terms of the ceRNA network, 120 mRNAs, 18 miRNAs, and 27 lncRNAs were shown in Hp-GA while 72 mRNAs, 8 miRNAs, and 1 lncRNA were included in the Hp-GC network.
In the cross-network, we found that immune regulation and differentiation regulation were important in the process of NO-GA.
Neuroendocrine regulation was mainly related to the process of GA-GC.
In the end, we verified that CDX2 plays an important role in the pathological process of NO to Hp-GA.
Comparing Hp-GA with Hp-GC, DEGs (FPR1, TFF2, GAST, SST, FUT9, and SHH), TF, and GATA5 were of great significance.
Conclusions.
We identified the DEGs, and their lncRNA regulatory network of Hp-associated diseases might provide insights into the mechanism between Hp infection and GC.
Furthermore, in-depth studies of the molecules might be useful to explore the multistep process of gastric diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Songyi& Yin, Honghao& Zheng, Shuwen& Chu, Aining& Li, Yizhi& Xing, Chengzhong…[et al.]. 2020. Differentially Expressed mRNAs and Their Long Noncoding RNA Regulatory Network with Helicobacter pylori-Associated Diseases including Atrophic Gastritis and Gastric Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1132886
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Songyi…[et al.]. Differentially Expressed mRNAs and Their Long Noncoding RNA Regulatory Network with Helicobacter pylori-Associated Diseases including Atrophic Gastritis and Gastric Cancer. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1132886
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Songyi& Yin, Honghao& Zheng, Shuwen& Chu, Aining& Li, Yizhi& Xing, Chengzhong…[et al.]. Differentially Expressed mRNAs and Their Long Noncoding RNA Regulatory Network with Helicobacter pylori-Associated Diseases including Atrophic Gastritis and Gastric Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1132886
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132886
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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