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A Preclinical Porcine Model of Portal Vein Thrombosis in Liver Cirrhosis
المؤلفون المشاركون
Wang, Jian
Chen, Shiyao
Ma, Jing-Qin
Zhang, Wen
Zhang, Rui
Lu, Shenxin
Jiang, Ying-yi
Gu, Jun-ying
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
This study aimed at presenting a novel method of developing a porcine model of portal vein thrombosis (PVT) in cirrhosis by intravenous administration of thrombin and insertion of a fibered coil.
We further investigated changes of biochemical parameters, coagulation, and proinflammatory cytokine expression in the cirrhosis-PVT group.
Methods.
Twelve male pigs were randomized into the control group (n=3) and cirrhosis group (n=9).
In cirrhotic pigs, three were randomly selected to establish PVT by ultrasound-guided percutaneous puncture of the main portal vein (MPV) followed by intravenous thrombin administration and fibered coil insertion.
Thrombosis in the MPV was detected by abdominal enhanced computer tomography (CT).
The changes of hepatic function, coagulation system, and inflammation cytokines were compared among normal, cirrhosis, and cirrhosis with PVT groups.
Results.
As manifested by the presence of a filling defect in MPV on portal venous-phase CT angiography, fibrin thrombi were formed in the MPV in cirrhotic pigs within one week and persisted for four weeks.
Five weeks after surgery, abnormal liver functions occurred in association with PVT formation in cirrhosis.
Both coagulation and thromboelastography parameters showed that cirrhosis-PVT pigs exhibited a procoagulant state through hyperfunction of platelets and clotting factors.
Interleukin 6 (IL-6) as a potential inflammatory marker stimulated PVT-mediated inflammation activation in cirrhosis.
Conclusions.
Our study provides in vivo evidence that intravenous injection of a coil and thrombin into MPV under interventional guided devices enables a feasible method in thrombus creation.
Further exploration and validation of large-sample cases are required to characterize utilities of this model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Rui& Lu, Shenxin& Jiang, Ying-yi& Ma, Jing-Qin& Zhang, Wen& Gu, Jun-ying…[et al.]. 2020. A Preclinical Porcine Model of Portal Vein Thrombosis in Liver Cirrhosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132981
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Rui…[et al.]. A Preclinical Porcine Model of Portal Vein Thrombosis in Liver Cirrhosis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1132981
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Rui& Lu, Shenxin& Jiang, Ying-yi& Ma, Jing-Qin& Zhang, Wen& Gu, Jun-ying…[et al.]. A Preclinical Porcine Model of Portal Vein Thrombosis in Liver Cirrhosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132981
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132981
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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