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Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders
المؤلفون المشاركون
Yasukochi, Yoshiki
Nishimura, Takayuki
Ugarte, Juan
Ohnishi, Mayumi
Nishihara, Mika
Alvarez, Guillermo
Fukuda, Hideki
Mendoza, Victor
Aoyagi, Kiyoshi
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-17
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The physiological characteristics of Andean natives living at high altitudes have been investigated extensively, with many studies reporting that Andean highlanders have a higher hemoglobin (Hb) concentration than other highlander populations.
It has previously been reported that positive natural selection has acted independently on the egl-9 family hypoxia inducible factor 1 (EGLN1) gene in Tibetan and Andean highlanders and is related to Hb concentration in Tibetans.
However, no study has yet revealed the genetic determinants of Hb concentration in Andeans even though several single-nucleotide polymorphisms (SNPs) in EGLN1 have previously been examined.
Therefore, we explored the relationship between hematological measurements and tag SNPs designed to cover the whole EGLN1 genomic region in Andean highlanders living in Bolivia.
Our findings indicated that haplotype frequencies estimated from the EGLN1 SNPs were significantly correlated with Hb concentration in the Bolivian highlanders.
Moreover, we found that an Andean-dominant haplotype related to high Hb level may have expanded rapidly in ancestral Andean highlander populations.
Analysis of genotype data in an ~436.3 kb genomic region containing EGLN1 using public databases indicated that the population structure based on EGLN1 genetic markers in Andean highlanders was largely different from that in other human populations.
This finding may be related to an intrinsic or adaptive physiological characteristic of Andean highlanders.
In conclusion, the high Hb concentrations in Andean highlanders can be partly characterized by EGLN1 genetic variants.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yasukochi, Yoshiki& Nishimura, Takayuki& Ugarte, Juan& Ohnishi, Mayumi& Nishihara, Mika& Alvarez, Guillermo…[et al.]. 2020. Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1133169
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yasukochi, Yoshiki…[et al.]. Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1133169
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yasukochi, Yoshiki& Nishimura, Takayuki& Ugarte, Juan& Ohnishi, Mayumi& Nishihara, Mika& Alvarez, Guillermo…[et al.]. Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1133169
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133169
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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