Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma
المؤلفون المشاركون
Wang, Lixin
Cao, Ting
Yi, Shi-jie
Zhao, Juan-xia
Xiao, Jiao
Xie, Ni
Zeng, Zhi
Han, Qi
Tang, Hai-ou
Li, Yu-kun
Zou, Juan
Wu, Qing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-09
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Background.
The microliposome maintenance (MCM) complex, MCM2-7, is revealed to be involved in multiple cellular processes and plays a key role in the development and progression of human cancers.
However, the MCM complex remains poorly elaborated in hepatic carcinoma (HCC).
Methods.
In the study, we found the mRNA and protein level by bioinformatics.
We also explored the prognostic value, genetic alteration, interaction network, and functional enrichment of MCM2-7.
The MCM expression and correlation among these MCMs in HCC cell lines were identified by western blot.
Results.
MCM2-7 was significantly increased in HCC tissues compared to normal liver tissues.
The high level of MCM2-7 had a positive correlation with poor prognosis.
However, MCM2-7 alterations were not correlated with poor OS.
MCMs were both increased in HCC cell lines compared to the normal hepatocyte cell line.
Furthermore, the positive correlation was found among MCMs in HCC cell lines.
Conclusions.
The MCM complex was increased in HCC tissues and cell lines and negatively correlated with prognosis, which might be important biomarkers for HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Ting& Yi, Shi-jie& Wang, Lixin& Zhao, Juan-xia& Xiao, Jiao& Xie, Ni…[et al.]. 2020. Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1133300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Ting…[et al.]. Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma. BioMed Research International No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1133300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Ting& Yi, Shi-jie& Wang, Lixin& Zhao, Juan-xia& Xiao, Jiao& Xie, Ni…[et al.]. Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1133300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر