Sulforaphane Attenuates Isoproterenol-Induced Myocardial Injury in Mice
المؤلفون المشاركون
Wu, Yi
Song, Lijuan
Srilakshmi, Mudduluri
Saleem, T. S. Mohamed
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The development of isoproterenol- (ISO-) induced oxidative stress in the myocardium results in myocardial necrosis.
Sulforaphane (SFN-0.4% of sulforaphane from standardized broccoli sprout extract) possesses chemoprotective, antidiabetic, and antibacterial activities and is also active against cardiovascular-related problems due to its antioxidant properties.
This study was designed to investigate the cardioprotective effect of SFN against isoproterenol-induced myocardial injury in mice.
Healthy male Swiss albino mice weighing 20–30 g were used in this study.
These mice were randomly divided into five groups (n=6).
All the mice in the experimental groups received isoproterenol (5 mg/kg bw, via i.p.) consecutively for 2 days.
The mice were treated with SFN (4 mg/kg bw) and α-tocopherol (TCF) (10 mg/kg bw) by oral gavage for 1-7 days as pre- and posttreatment for the prophylactic and treatment groups, respectively.
On day 10, the following parameters were studied: heart weight to body weight ratio, antioxidant parameters, and cardiac markers; and mitochondrial enzymes were estimated for cardioprotection.
Administration of isoproterenol in mice showed an increased level of serum cardiac markers and heart mitochondrial ATPase enzymes.
An increased level of myocardial thiobarbituric acid-reactive substance and decreased levels of endogenous antioxidant enzymes indicated that oxidative stress is induced by isoproterenol in the myocardium.
The administration of SFN in mice restored the levels of all biochemical parameters to near-normal levels.
Histopathological studies further confirmed the protective effect of sulforaphane.
This study concluded that treatment with SFN boosts the endogenous antioxidant activity and prevents isoproterenol-induced myocardial injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Lijuan& Srilakshmi, Mudduluri& Wu, Yi& Saleem, T. S. Mohamed. 2020. Sulforaphane Attenuates Isoproterenol-Induced Myocardial Injury in Mice. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Lijuan…[et al.]. Sulforaphane Attenuates Isoproterenol-Induced Myocardial Injury in Mice. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1133342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Lijuan& Srilakshmi, Mudduluri& Wu, Yi& Saleem, T. S. Mohamed. Sulforaphane Attenuates Isoproterenol-Induced Myocardial Injury in Mice. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر