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Upregulation of PDGF Mediates Robust Liver Regeneration after Nanosecond Pulsed Electric Field Ablation by Promoting the HGFc-Met Pathway
المؤلفون المشاركون
Zhou, Lin
Qian, Junjie
Liu, Jianpeng
Hong, Liangjie
Lu, Haohao
Guo, Danjing
Liu, Zhen
Yin, Shengyong
Zheng, Shusen
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Nanosecond pulsed electric field (nsPEF) has emerged as a promising tool for hepatocellular carcinoma ablation recently.
However, little is known about how nsPEF affects liver regeneration while being applied to eliminate liver lesions.
Besides, the impact of nsPEF ablation on liver function should also be taken into consideration in the process.
In this paper, we study the impact of nsPEF ablation on liver function by the measurement of serum levels of AST and ALT as well as liver regeneration and relevant molecular mechanisms in vivo.
We found that mouse liver function exhibited a temporary injury without weight loss after ablation.
In addition, local hepatic nsPEF ablation promoted significant proliferation of hepatocytes of the whole liver with an increase in HGF level.
Moreover, the proliferation of hepatocytes was dramatically inhibited by the inhibitor of c-Met.
Of interest, the periablational area is characterized by high level of PDGF and a large amount of activated hepatic stellate cells.
Furthermore, neutralizing PDGF was able to significantly inhibit liver regeneration, the increased HGF level, and the accumulation of activated HSCs.
Our findings demonstrated that nsPEF not only was a safe ablation approach but also could stimulate the regeneration of the whole liver through the activation of the HGF/c-Met pathway by upregulation of PDGF within the periablational zone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qian, Junjie& Liu, Jianpeng& Hong, Liangjie& Lu, Haohao& Guo, Danjing& Liu, Zhen…[et al.]. 2020. Upregulation of PDGF Mediates Robust Liver Regeneration after Nanosecond Pulsed Electric Field Ablation by Promoting the HGFc-Met Pathway. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qian, Junjie…[et al.]. Upregulation of PDGF Mediates Robust Liver Regeneration after Nanosecond Pulsed Electric Field Ablation by Promoting the HGFc-Met Pathway. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qian, Junjie& Liu, Jianpeng& Hong, Liangjie& Lu, Haohao& Guo, Danjing& Liu, Zhen…[et al.]. Upregulation of PDGF Mediates Robust Liver Regeneration after Nanosecond Pulsed Electric Field Ablation by Promoting the HGFc-Met Pathway. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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