Prognostic Value of Complement Component 2 and Its Correlation with Immune Infiltrates in Hepatocellular Carcinoma
المؤلفون المشاركون
Peng, Liang
Ning, Gang
Xie, Chan
Xu, Wen-xiong
Huang, Yan-Lin
Zhen, Li-Min
Li, Xue-Jun
Wu, Li-Na
Liu, Ying
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC).
However, little is known about the role and mechanism of C2 in HCC.
In the present study, we aimed to explore the prognostic value of C2 and its correlation with tumor-infiltrating immune cells in HCC.
Materials and Methods.
mRNA expression was downloaded from TCGA (365 HCC patients and 50 healthy controls), GSE14520 (220 HCC patients and 220 adjacent normal tissues), and ICGC HCC (232 HCC patients) cohorts.
Unpaired Student’s t-tests or ANOVA tests were used to evaluate differences of C2 expression.
Univariate and multivariate analyses were used to analyze the prognostic value of C2.
CIBERSORT was used to calculate the proportion of 22 kinds of tumor-infiltrating immune cells.
Results.
Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages.
Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC.
Moreover, elevated CD4 T cells were found at HCC patients with higher C2 expression while the higher proportion of macrophage M0 cells was found in HCC patients with lower C2 expression.
KEGG analysis showed that “cell cycle,” “AMPK signaling pathway,” and “PPAR signaling pathway” were enriched in HCC patients with higher C2 expression.
Conclusion.
C2 is a prognostic factor for HCC and may be used as a therapeutic target for future treatment of HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ning, Gang& Huang, Yan-Lin& Zhen, Li-Min& Xu, Wen-xiong& Li, Xue-Jun& Wu, Li-Na…[et al.]. 2020. Prognostic Value of Complement Component 2 and Its Correlation with Immune Infiltrates in Hepatocellular Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133414
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ning, Gang…[et al.]. Prognostic Value of Complement Component 2 and Its Correlation with Immune Infiltrates in Hepatocellular Carcinoma. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1133414
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ning, Gang& Huang, Yan-Lin& Zhen, Li-Min& Xu, Wen-xiong& Li, Xue-Jun& Wu, Li-Na…[et al.]. Prognostic Value of Complement Component 2 and Its Correlation with Immune Infiltrates in Hepatocellular Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133414
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133414
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر