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Transcriptome Profiling across Five Tissues of Giant Panda
المؤلفون المشاركون
Li, Diyan
Li, Feng
Wang, Chengdong
Xu, Zhongxian
Li, Mingzhou
Deng, Linhua
Wei, Ming
Zhang, Hemin
Wu, Kai
Ning, Ruihong
Yang, Mingyao
Zhang, Mingwang
Ni, Qingyong
Zeng, Bo
Li, Desheng
Li, Ying
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Gene differential expression studies can serve to explore and understand the laws and characteristics of animal life activities, and the difference in gene expression between different animal tissues has been well demonstrated and studied.
However, for the world-famous rare and protected species giant panda (Ailuropoda melanoleuca), only the transcriptome of the blood and spleen has been reported separately.
Here, in order to explore the transcriptome differences between the different tissues of the giant panda, transcriptome profiles of the heart, liver, spleen, lung, and kidney from five captive giant pandas were constructed with Illumina HiSeq 2500 platform.
The comparative analysis of the intertissue gene expression patterns was carried out based on the generated RNA sequencing datasets.
Analyses of Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and protein-protein interaction (PPI) network were performed according to the identified differentially expressed genes (DEGs).
We generated 194.52 GB clean base data from twenty-five sequencing libraries and identified 18,701 genes, including 3492 novel genes.
With corrected p value <0.05 and |log2FoldChange| >2, we finally obtained 921, 553, 574, 457, and 638 tissue-specific DEGs in the heart, liver, spleen, lung, and kidney, respectively.
In addition, we identified TTN, CAV3, LDB3, TRDN, and ACTN2 in the heart; FGA, AHSG, and SERPINC1 in the liver; CD19, CD79B, and IL21R in the spleen; NKX2-4 and SFTPB in the lung; GC and HRG in the kidney as hub genes in the PPI network.
The results of the analyses showed a similar gene expression pattern between the spleen and lung.
This study provided for the first time the heart, liver, lung, and kidney’s transcriptome resources of the giant panda, and it provided a valuable resource for further genetic research or other potential research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Feng& Wang, Chengdong& Xu, Zhongxian& Li, Mingzhou& Deng, Linhua& Wei, Ming…[et al.]. 2020. Transcriptome Profiling across Five Tissues of Giant Panda. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1133476
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Feng…[et al.]. Transcriptome Profiling across Five Tissues of Giant Panda. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1133476
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Feng& Wang, Chengdong& Xu, Zhongxian& Li, Mingzhou& Deng, Linhua& Wei, Ming…[et al.]. Transcriptome Profiling across Five Tissues of Giant Panda. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1133476
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133476
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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