Identification of Genes Associated with the Metastasis of PheochromocytomaParaganglioma Based on Weighted Gene Coexpression Network Analysis
المؤلفون المشاركون
Su, Qi-Sheng
Mo, Wuning
Ding, Qinpei
Zhang, Zunni
Yang, Zheng
Qiu, Yuling
Li, Xiaohong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Pheochromocytoma/paraganglioma (PCPG) is a benign neuroendocrine neoplasm in most cases, but metastasis and other malignant behaviors can be observed in this tumor.
The aim of this study was to identify genes associated with the metastasis of PCPG.
Methods.
The Cancer Genome Atlas (TCGA) expression profile data and clinical information were downloaded from the cbioportal, and the weighted gene coexpression network analysis (WGCNA) was conducted.
The gene coexpression modules were extracted from the network through the WGCNA package of R software.
We further extracted metastasis-related modules of PCPG.
Enrichment analysis of Biological Process of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes was carried out for important modules, and survival analysis of hub genes in the modules was performed.
Results.
A total of 168 PCPG samples were included in this study.
The weighted gene coexpression network was constructed with 5125 genes of the top 25% variance among the 20501 genes obtained from the database.
We identified 11 coexpression modules, among which the salmon module was associated with the age of PCPG patients at diagnosis, metastasis, and malignancy of the tumors.
Conclusion.
WGCNA was performed to identify the gene coexpression modules and hub genes in the metastasis-related gene module of PCPG.
The findings in this study provide a new clue for further study of the mechanisms underlying the PCPG metastasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Qi-Sheng& Ding, Qinpei& Zhang, Zunni& Yang, Zheng& Qiu, Yuling& Li, Xiaohong…[et al.]. 2020. Identification of Genes Associated with the Metastasis of PheochromocytomaParaganglioma Based on Weighted Gene Coexpression Network Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133524
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Qi-Sheng…[et al.]. Identification of Genes Associated with the Metastasis of PheochromocytomaParaganglioma Based on Weighted Gene Coexpression Network Analysis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1133524
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Qi-Sheng& Ding, Qinpei& Zhang, Zunni& Yang, Zheng& Qiu, Yuling& Li, Xiaohong…[et al.]. Identification of Genes Associated with the Metastasis of PheochromocytomaParaganglioma Based on Weighted Gene Coexpression Network Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133524
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133524
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر