Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p
المؤلفون المشاركون
Mo, Wei Lie
Jiang, Jing Ting
Zhang, Luo
Lu, Qi Cheng
Li, Jing
Gu, Wei Dong
Cheng, Yun
Wang, Hai Tao
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Circular RNAs are a class of endogenous noncoding RNAs that play an important role in gene regulation.
These RNAs are involved in the development and progression of various cancers, but their roles in gastric cancer have not yet been thoroughly elucidated.
This study showed that hsa_circ_0000467 expression was higher in gastric cancer tissues than in corresponding adjacent tissues (P<0.050) and that hsa_circ_0000467 expression levels were correlated with gastric cancer histological grade (P<0.050).
In addition, hsa_circ_0000467 was remarkably upregulated in gastric cancer cell lines (P<0.001).
Cell function experiments indicated that hsa_circ_0000467 downregulation decreased the proliferation and invasion ability of BGC-823 and SGC-7901 cells and the number of cells entering the G2/M phase.
A direct binding interaction was detected between hsa_circ_0000467 and miR-326-3p by dual-luciferase reporter assays.
In addition, the results showed that inhibition of miR-326-3p reversed the decreases in the proliferation and invasion of BGC-823 and SGC-7901 cells caused by hsa_circ_0000647 downregulation.
Inhibition of miR-326-3p also decreased the number of cells entering the G2/M phase and the expression of cyclin D1.
In conclusion, hsa_circ_0000467 plays a regulatory role in the development and progression of gastric cancer by regulating miR-326-3p, and this circRNA may be a potential diagnostic marker and therapeutic target of gastric cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mo, Wei Lie& Jiang, Jing Ting& Zhang, Luo& Lu, Qi Cheng& Li, Jing& Gu, Wei Dong…[et al.]. 2020. Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133639
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mo, Wei Lie…[et al.]. Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133639
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mo, Wei Lie& Jiang, Jing Ting& Zhang, Luo& Lu, Qi Cheng& Li, Jing& Gu, Wei Dong…[et al.]. Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133639
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133639
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر