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Identifying Compound Effect of Drugs on Rheumatoid Arthritis Treatment Based on the Association Rule and a Random Walking-Based Model
المؤلفون المشاركون
Fang, Yanyan
Liu, Jian
Xin, Ling
Sun, Yue
Wan, Lei
Huang, Dan
Wen, Jianting
Zhang, Ying
Wang, Bing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that is diagnosed mainly on the basis of patient signs, symptoms, and laboratory indices.
However, the exact causes of RA are unclear.
Moreover, there is a lack of any method of dynamically evaluating the efficacy of the medication administered to treat RA.
Here, we applied a random walk model to reveal the compatibility among the various constituents of traditional Chinese medicine and evaluate their therapeutic efficacy against RA.
Drugs commonly used to treat RA were investigated using cluster analysis.
The association rule analysis was applied to identify compatibilities among the constituents.
A random walk model was developed to evaluate drug efficacy based on an in-house database comprising the clinical records of 9,408 RA patients.
Frequently administered medicines were combined into three correlated sets.
The evaluation based on the random walk method showed that the drug combination improved ESR, CRP, C3, C4, and IgA more effectively than any single drug.
The present study demonstrated that the TCM constituents complement each other and various combinations of them produce different therapeutic effects on RA treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fang, Yanyan& Liu, Jian& Xin, Ling& Sun, Yue& Wan, Lei& Huang, Dan…[et al.]. 2020. Identifying Compound Effect of Drugs on Rheumatoid Arthritis Treatment Based on the Association Rule and a Random Walking-Based Model. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133647
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fang, Yanyan…[et al.]. Identifying Compound Effect of Drugs on Rheumatoid Arthritis Treatment Based on the Association Rule and a Random Walking-Based Model. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133647
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fang, Yanyan& Liu, Jian& Xin, Ling& Sun, Yue& Wan, Lei& Huang, Dan…[et al.]. Identifying Compound Effect of Drugs on Rheumatoid Arthritis Treatment Based on the Association Rule and a Random Walking-Based Model. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133647
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133647
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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