Association between Genetic Polymorphism and Risk of von Willebrand Disease in Pakistan
المؤلفون المشاركون
Arshad, Najma
Nawaz, Syed Kashif
Iqbal, Riffat
Arshad, Muhammad
Musheer, Farhana
Naz, Amber
Mushtaq, Iqra
Jaleel, Sara
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-20
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
von Willebrand disease (VWD) is an inherited, genetically and clinically heterogeneous hemorrhagic disorder.
The most common cause of this disease is mutation in the gene that encodes protein von Willebrand factor (VWF) which is responsible for blood clotting.
The current study was designed to investigate the role of genetic polymorphisms with the onset of VWD in population of Pakistan.
Three exonic variants (c.3445T>C; c.4975C>T; c.7603C>T) from VWF gene were used for the genotyping purpose.
The current study employed a case-control association design involving 43 VWD patients and 100 healthy controls from Pakistani population.
The genetic reason of VWD was investigated using the allele specific PCR.
The significant (P<0.05) allelic association was found between all three exonic variants and VWD.
The CT genotype of these variants was noticed to be associated with significantly higher risk of VWD [odds ratio (95% CI): 14.7 (4.546–47.98), 26.71 (7.281–97.98), and 21.5 (5.806–80.01) for c.3445T>C, c.4975C>T, and c.7603C>T, resp.] while genotypes CC (c.4975C>T) and TT (c.3445T>C and c.7603C>T) were having protective effect against the disease.
However, replicated studies are needed for elaborating the role of these SNPs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arshad, Najma& Nawaz, Syed Kashif& Iqbal, Riffat& Arshad, Muhammad& Musheer, Farhana& Naz, Amber…[et al.]. 2017. Association between Genetic Polymorphism and Risk of von Willebrand Disease in Pakistan. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1133657
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arshad, Najma…[et al.]. Association between Genetic Polymorphism and Risk of von Willebrand Disease in Pakistan. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1133657
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arshad, Najma& Nawaz, Syed Kashif& Iqbal, Riffat& Arshad, Muhammad& Musheer, Farhana& Naz, Amber…[et al.]. Association between Genetic Polymorphism and Risk of von Willebrand Disease in Pakistan. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1133657
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133657
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر