![](/images/graphics-bg.png)
Dysregulated Bone Metabolism Is Related to High Expression of miR-151a-3p in Severe Adolescent Idiopathic Scoliosis
المؤلفون المشاركون
Li, Jiong
Wang, Yunjia
Zhang, Hongqi
Yang, Guanteng
Xiao, Lige
Guo, Chaofeng
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Adolescent idiopathic scoliosis (AIS) is a common complex disease, and bone homeostasis plays an important role in its pathogenesis.
Recent advances in epigenetic research show that dysregulated miRNAs may participate in the development of orthopedic diseases and AIS.
The aim of this study was to detect differentially expressed miRNAs in severe AIS and elucidate the mechanism of miRNA deregulation in the pathogenesis of AIS.
In the present study, miRNA expression profiles were detected in severe and mild AIS patients as well as healthy controls by miRNA sequencing.
Candidate miRNAs were validated in a larger cohort.
Primary osteoblasts from severe AIS patients were extracted and isolated to determine the effect of the candidate miRNAs on bone metabolism.
Finally, we determined the methylation level in primary osteoblasts from severe AIS patients.
The result showed that miR-151a-3p was overexpressed in severe AIS patients.
Reduced GREM1 expression was observed in primary osteoblasts from severe AIS patients.
miR-151a-3p directly inhibited GREM1 in primary osteoblasts.
Relatively lower methylation levels were detected in primary osteoblasts from severe AIS patients.
In conclusion, our study revealed that plasma miR-151a-3p levels may serve as a biomarker for severe AIS.
Overexpression of miR-151a-3p may interrupt bone homeostasis via inhibiting GREM1 expression.
Our result may provide a new biomarker for the early detection of AIS and increase our understanding of the pathogenesis of AIS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yunjia& Zhang, Hongqi& Yang, Guanteng& Xiao, Lige& Li, Jiong& Guo, Chaofeng. 2020. Dysregulated Bone Metabolism Is Related to High Expression of miR-151a-3p in Severe Adolescent Idiopathic Scoliosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133803
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yunjia…[et al.]. Dysregulated Bone Metabolism Is Related to High Expression of miR-151a-3p in Severe Adolescent Idiopathic Scoliosis. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1133803
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yunjia& Zhang, Hongqi& Yang, Guanteng& Xiao, Lige& Li, Jiong& Guo, Chaofeng. Dysregulated Bone Metabolism Is Related to High Expression of miR-151a-3p in Severe Adolescent Idiopathic Scoliosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133803
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133803
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)