![](/images/graphics-bg.png)
L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221
المؤلفون المشاركون
Zhang, Hexi
Wang, Li
Peng, Fei
Wang, Xin
Gong, Hui
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
Atherosclerosis (AS) is a severe disease in which the inside of an artery narrows because of plaque formation, leading to endothelial injury in the patients.
Although it has been found that endothelial nitric oxide synthase (eNOS), which produces a low concentration of NO, is necessary for endothelial function and integrity, the regulatory mechanisms of eNOS expression against the pathogenesis and development of AS are unclear.
Evidence has indicated that diet supplementation with L-arginine could reduce the size of the endothelial injury lesions in AS patients.
In addition, nonencoding microRNAs (miRNAs) were found to be a promising tool that regulates the expression of eNOS in human endothelial cells.
Design.
The aim of this research was to explore the role of L-arginine in the development of AS and the mechanisms by which miR-221 influences the possible signaling pathways in endothelial cells during AS.
Results.
The results suggested that L-arginine could prevent oxidized low-density lipoprotein-induced apoptosis in endothelial cells, which is associated with the downregulation of miR-221.
Similar results were also observed in rat AS models.
Conclusion.
This research could provide potential therapies for the treatment of AS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Hexi& Wang, Li& Peng, Fei& Wang, Xin& Gong, Hui. 2020. L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Hexi…[et al.]. L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1133868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Hexi& Wang, Li& Peng, Fei& Wang, Xin& Gong, Hui. L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)