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A Study of 358 Cases of Locally Advanced Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiation Therapy: Improving the Seventh Edition of the American Joint Committee on Cancer T-Staging System
المؤلفون المشاركون
Zhou, Qin
He, Yuxiang
Zhao, Yajie
Wang, Yin
Kuang, Weilu
Shen, Liangfang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
To evaluate the rationality and limitations of the seventh edition of the American Joint Committee on Cancer (the 7th AJCC edition) T-staging system for locally advanced nasopharyngeal carcinoma (NPC).
The prognosis of 358 patients with stage T3/T4 NPC treated with intensity-modulated radiotherapy (IMRT) was analyzed with the Kaplan–Meier method or the log-rank test.
The 7th AJCC staging system of NPC has some limitations in that the T category is neither the significant factor in OS/LRFS nor the independent prognostic factor in OS/LRFS/DMFS/DFS ( P > 0.05 ).
After adjustment by anatomic structures, univariate analysis has shown that the adjusted-T category has statistical significance between T3 and T4 for OS (86.4% and 71.3%, P = 0.002 ), LRFS (97% and 90.9%, P = 0.048 ), DMFS (90.9% and 77.2%, P = 0.001 ), and DFS (86.2% and 67.5%, P = 0.000 ), and multivariate analysis has shown that the adjusted-T category is an independent prognostic factor for OS/DMFS/DFS (with the exception of LRFS).
Then, GTV-P was taken into consideration.
Multivariate analysis showed that these nT categories serve as suitable independent prognostic factors for OS/DMFS/DFS ( P < 0.001 ) and LRFS (HR = 3.131; 95% CI, 1.090–8.990; P = 0.0 43 ).
The 7th AJCC staging system has limitations and should be improved by including the modifications suggested, such as anatomic structures and tumor volume adjustment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Qin& He, Yuxiang& Zhao, Yajie& Wang, Yin& Kuang, Weilu& Shen, Liangfang. 2017. A Study of 358 Cases of Locally Advanced Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiation Therapy: Improving the Seventh Edition of the American Joint Committee on Cancer T-Staging System. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1133911
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Qin…[et al.]. A Study of 358 Cases of Locally Advanced Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiation Therapy: Improving the Seventh Edition of the American Joint Committee on Cancer T-Staging System. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1133911
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Qin& He, Yuxiang& Zhao, Yajie& Wang, Yin& Kuang, Weilu& Shen, Liangfang. A Study of 358 Cases of Locally Advanced Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiation Therapy: Improving the Seventh Edition of the American Joint Committee on Cancer T-Staging System. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1133911
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133911
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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