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Role of the AMPKACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation
المؤلفون المشاركون
Du, Juan
Chen, Lei
Lin, Zhangying
Zhu, Junwei
Shen, Bing
Wu, Kaile
Liu, Yehai
Fang, Yang
Li, Kun
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Transient receptor potential polycystic 2 (TRPP2) exerts vital roles in various types of cancer; however, its underlying mechanisms remain largely unknown.
This study is aimed at investigating whether knockdown of TRPP2 affected the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and the proliferation of HN-4, cell line originating from human oral and hypopharyngeal squamous cell carcinoma.
In addition, the interactions among AMPK/ACC, AMPK/protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2α (eIF2α) and TRPP2/PERK/eIF2α signaling pathways, and their association with cell proliferation were also explored.
The results showed that the relative expression levels of phosphorylated (p)-ACC, p-PERK, and p-eIF2α in HN-4 cells were significantly increased following treatment with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) and significantly decreased in cells treated with compound C.
Therefore, consistent with previous studies, the AMPK/ACC and AMPK/PERK/eIF2α signaling pathways were upregulated and downregulated following treatment with an AMPK agonist and inhibitor, respectively.
Furthermore, TRPP2 knockdown decreased p-PERK and p-eIF2α expression levels and increased those of p-AMPK and p-ACC.
Additionally, knockdown of TRPP2 increased HN-4 cell proliferation, while treatment with an AMPK inhibitor or agonist increased or inhibited TRPP2-specific siRNA-mediated cell proliferation, respectively.
In conclusion, silencing of TRPP2 expression increased HN-4 cell proliferation via inhibiting the PERK/eIF2α signaling pathway, while the AMPK/ACC signaling pathway was possibly activated by a feedback mechanism to reduce enhanced cell proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Kun& Chen, Lei& Lin, Zhangying& Zhu, Junwei& Fang, Yang& Du, Juan…[et al.]. 2020. Role of the AMPKACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133914
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Kun…[et al.]. Role of the AMPKACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1133914
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Kun& Chen, Lei& Lin, Zhangying& Zhu, Junwei& Fang, Yang& Du, Juan…[et al.]. Role of the AMPKACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133914
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133914
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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