The Incremental Prognostic Value of Baseline 18F-FDG PETCT Imaging in Angioimmunoblastic T-Cell Lymphoma

الملخص EN

Background and Purpose.

Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of peripheral T-cell lymphoma with rapid disease progression and poor prognosis.

The aim of this study was to determine the incremental prognostic value of baseline 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in addition to clinical prognostic factors.

Methods.

From January 2010 to October 2019, a total of 23 patients who pathologically confirmed to have AITL were retrospectively analyzed.

All patients underwent whole-body 18F-FDG PET/CT scan before chemotherapy.

The 18F-FDG PET/CT features, clinical data, laboratory indicators, Ki67 labeling index, and survival status were collected and analyzed.

Results.

The median follow-up was 22 months.

The expected 1-, 2-, and 3-year survival rate was 72.2%, 49.6%, and 42.5%, respectively.

The median overall survival (OS) was 23 months (95% confidence interval (CI): 8.459~37.541).

AITL is prone to extranodal infiltration, in addition to nodal infiltration (6 patients had nodal infiltration alone, and 17 patients had both nodal and extranodal infiltration).

The SUVmax of nodal lesions were higher than that for the extranodal lesions (10.43±4.45, 6.64±3.51, F=2.78, t=4.39, P<0.01).

On multivariate survival analysis, the Eastern Cooperative Oncology Group (ECOG) and SUVmax of extranodal lesions were independent predictors of OS.

Conclusion.

Baseline 18F-FDG PET/CT results and SUVmax of extranodal lesions showed an incremental prognostic value in addition to clinical prognostic factors.