Bioinformatic Analysis of Neuroimmune Mechanism of Neuropathic Pain
المؤلفون المشاركون
Feng, Shiqing
Yu, Hao
Liu, Yang
Li, Chao
Wang, Jianhao
Yu, Bo
Wu, Qiang
Xiang, Ziqian
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Neuropathic pain (NP) is a devastating complication following nerve injury, and it can be alleviated by regulating neuroimmune direction.
We aimed to explore the neuroimmune mechanism and identify some new diagnostic or therapeutic targets for NP treatment via bioinformatic analysis.
Methods.
The microarray GSE18803 was downloaded and analyzed using R.
The Venn diagram was drawn to find neuroimmune-related differentially expressed genes (DEGs) in neuropathic pain.
Gene Ontology (GO), pathway enrichment, and protein-protein interaction (PPI) network were used to analyze DEGs, respectively.
Besides, the identified hub genes were submitted to the DGIdb database to find relevant therapeutic drugs.
Results.
A total of 91 neuroimmune-related DEGs were identified.
The results of GO and pathway enrichment analyses were closely related to immune and inflammatory responses.
PPI analysis showed two important modules and 8 hub genes: PTPRC, CD68, CTSS, RAC2, LAPTM5, FCGR3A, CD53, and HCK.
The drug-hub gene interaction network was constructed by Cytoscape, and it included 24 candidate drugs and 3 hub genes.
Conclusion.
The present study helps us better understand the neuroimmune mechanism of neuropathic pain and provides some novel insights on NP treatment, such as modulation of microglia polarization and targeting bone resorption.
Besides, CD68, CTSS, LAPTM5, FCGR3A, and CD53 may be used as early diagnostic biomarkers and the gene HCK can be a therapeutic target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Hao& Liu, Yang& Li, Chao& Wang, Jianhao& Yu, Bo& Wu, Qiang…[et al.]. 2020. Bioinformatic Analysis of Neuroimmune Mechanism of Neuropathic Pain. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133964
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Hao…[et al.]. Bioinformatic Analysis of Neuroimmune Mechanism of Neuropathic Pain. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133964
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Hao& Liu, Yang& Li, Chao& Wang, Jianhao& Yu, Bo& Wu, Qiang…[et al.]. Bioinformatic Analysis of Neuroimmune Mechanism of Neuropathic Pain. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133964
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133964
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر