Anion Gap Was Associated with Inhospital Mortality and Adverse Clinical Outcomes of Coronary Care Unit Patients
المؤلفون المشاركون
Zhou, Yujie
Shen, Hua
Sun, Tienan
Cai, Chenghui
Yang, Jiaqi
Guo, Qianyun
Zhang, Jingrui
Zhang, Biyang
Ding, Yaodong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Anion gap (AG) has been proved to be associated with prognosis of many cardiovascular diseases.
This study is aimed at exploring the association of AG with inhospital all-cause mortality and adverse clinical outcomes in coronary care unit (CCU) patients.
Method.
All data of this study was extracted from Medical Information Mart for Intensive Care III (MIMIC-III, version 1.4) database.
All patients were divided into four groups according to AG quartiles.
Primary outcome was inhospital all-cause mortality.
Lowess smoothing curve was drawn to describe the overall trend of inhospital mortality.
Binary logistic regression analysis was performed to determine the independent effect of AG on inhospital mortality.
Result.
A total of 3593 patients were enrolled in this study.
In unadjusted model, as AG quartiles increased, inhospital mortality increased significantly, OR increased stepwise from quartile 2 (OR, 95% CI: 1.01, 0.74-1.38, P=0.958) to quartile 4 (OR, 95% CI: 2.72, 2.08-3.55, P<0.001).
After adjusting for possible confounding variables, this association was attenuated, but still remained statistically significant (quartile 1 vs.
quartile 4: OR, 95% CI: 1.02, 0.72-1.45 vs.
1.49, 1.07-2.09, P=0.019).
Moreover, CCU mortality (P<0.001) and rate of acute kidney injury (P<0.001) were proved to be higher in the highest AG quartiles.
Length of CCU (P<0.001) and hospital stay (P<0.001) prolonged significantly in higher AG quartiles.
Maximum sequential organ failure assessment score (SOFA) (P<0.001) and simplified acute physiology score II (SAPSII) (P<0.001) increased significantly as AG quartiles increased.
Moderate predictive ability of AG on inhospital (AUC: 0.6291), CCU mortality (AUC: 0.6355), and acute kidney injury (AUC: 0.6096) was confirmed.
The interactions were proved to be significant in hypercholesterolemia, congestive heart failure, chronic lung disease, respiratory failure, oral anticoagulants, Beta-blocks, angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB), and vasopressin treatment subgroups.
Conclusion.
AG was an independent risk factor of inhospital all-cause mortality and was associated with adverse clinical outcomes in CCU patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Tienan& Cai, Chenghui& Shen, Hua& Yang, Jiaqi& Guo, Qianyun& Zhang, Jingrui…[et al.]. 2020. Anion Gap Was Associated with Inhospital Mortality and Adverse Clinical Outcomes of Coronary Care Unit Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Tienan…[et al.]. Anion Gap Was Associated with Inhospital Mortality and Adverse Clinical Outcomes of Coronary Care Unit Patients. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1134017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Tienan& Cai, Chenghui& Shen, Hua& Yang, Jiaqi& Guo, Qianyun& Zhang, Jingrui…[et al.]. Anion Gap Was Associated with Inhospital Mortality and Adverse Clinical Outcomes of Coronary Care Unit Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر